Longitudinal evaluation of serovar-specific immunity to Neisseria gonorrhoeae
Longitudinal evaluation of serovar-specific immunity to Neisseria gonorrhoeae
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DOI：
10.1093/oxfordjournals.aje.a009820
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发表时间：
1999-02-15
影响因子：
5
通讯作者：
Cohen, MS
中科院分区：
文献类型：
--
作者：
Fox, KK;Thomas, JC;Cohen, MS
在一个群落中占主导地位的淋球菌的血清型随着时间的推移而变化，这一现象可能是由于对同一血清型重复感染的免疫力的发展所致。本研究评价了淋病奈瑟菌血清型特异性免疫的流行病学证据。在1992-1994年的17个月期间，北卡罗来纳州农村一家性传播疾病诊所的所有来访者都接受了淋病奈瑟菌的生殖器培养。淋球菌分离株按标准方法进行血清学分型。根据再次感染时社区中血清型的分布情况，计算同一血清型与任何不同血清型重复感染的优势比。在2838名患者中，608人(21.4%；427名男性和181名女性)在初次就诊时被发现感染淋病奈瑟菌。在608名患者中，90名患者(14.8%)有112例重复淋球菌感染，根据再次感染时社区流行的血清型，相同血清型的重复感染发生的频率略高于预期，但结果并不显著(优势比=1.5，95%可信区间1.0-2.4；p=0.05)。在性网络中选择伴侣可能会增加重复接触相同淋病奈瑟菌血清型的可能性。淋球菌感染不能诱导对同一血清型再次感染的明显免疫力。
The serovars of Neisseria gonorrhoeae that are predominant in a community change over time, a phenomenon that may be due to the development of immunity to repeat infection with the same serovar. This study evaluated the epidemiologic evidence for serovar-specific immunity to N. gonorrhoeae. During a 17-month period in 1992-1994, all clients of a sexually transmitted disease clinic in rural North Carolina underwent genital culture for N. gonorrhoeae. Gonococcal isolates were serotyped according to standard methods. Odds ratios for repeat infection with the same serovar versus any different serovar were calculated on the basis of the distribution of serovars in the community at the time of reinfection. Of 2,838 patients, 608 (21.4%; 427 males and 181 females) were found to be infected with N. gonorrhoeae at the initial visit. Ninety patients (14.8% of the 608) had a total of 112 repeal gonococcal infections, Repeat infection with the same serovar occurred slightly more often than would be expected based on the serovars prevalent in the community at the time of reinfection, though the result was marginally nonsignificant (odds ratio = 1.5, 95% confidence interval 1.0-2.4; p = 0.05). Choosing partners within a sexual network may increase the likelihood of repeat exposure to the same serovar of N. gonorrhoeae. Gonococcal infection did not induce evident immunity to reinfection with the same serovar.