[18F]FLT PET for diagnosis and staging of thoracic tumours
[18F]FLT PET for diagnosis and staging of thoracic tumours
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DOI：
10.1007/s00259-003-1257-3
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发表时间：
2003-10-01
影响因子：
9.1
通讯作者：
Bares, R
中科院分区：
文献类型：
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作者：
Dittmann, H;Dohmen, BM;Bares, R
Micleoside类似物3 '-deoxy-3'-[F-18]-fluorothyrnidine（FLT）已被引入用于通过正电子发射断层扫描（PET）成像肿瘤细胞增殖。本研究评价了FLT在胸部肿瘤患者治疗前的应用。在治疗前对16例患者的18种肿瘤[17种胸部肿瘤（9种非小细胞肺癌、5种食管癌、2种肉瘤、1种霍奇金淋巴瘤）和1种肾癌]进行了全身FLT PET。除食管癌患者外，其他患者均行18氟脱氧葡萄糖（FDG）PET检查。对于半定量分析，平均和最大标准化摄取值（分别为avgSUV和maxSUV）（FLT，114 +/- 20 min p.i.; FDG，87 ± 8 min p.i.; 50%等值线感兴趣区域）。所有17例胸部肿瘤和19/20例转移瘤均显示出显著的FLT蓄积，从而易于从周围组织中勾画出轮廓。FLT或FDG均未检测到额外的I级小肾癌。在大多数肺肿瘤（平均SUV 1.5-8.2）和转移瘤中，FLT显示出强烈的摄取。然而，由于周围骨髓中的高生理FLT摄取，两个脊柱骨转移瘤中的一个被遗漏。原发性食管癌（平均SUV 2.7-10.0）和偶尔转移显示出特别有利的肿瘤/非肿瘤对比度。与FDG相比，FLT的肿瘤摄取率较低（avgSUV，P=0.0006; maxSUV，P=0.0001），且FLT与FDG之间具有显著的线性相关性（avgSUV，r（2）=0.45，maxSUV，r（2）=0.49）。可以得出结论，FLT PET准确地可视化胸部肿瘤病变。在肝脏和骨髓中，高生理性FLT摄取阻碍转移的检测。另一方面，FLT可能有利于脑转移瘤的成像，由于低生理摄取。
The micleoside analogue 3'-deoxy-3'-[F-18]-fluorothyrnidine (FLT) has been introduced for imaging of tumour cell proliferation by positron emission tomography (PET). This study evaluated the use of FLT in patients with thoracic tumours prior to treatment. Whole-body FLT PET was performed in 16 patients with 18 tumours [17 thoracic tumours (nine non-small cell lung cancers, five oesophageal carcinomas, two sarcomas, one Hodgkin's lymphoma) and one renal carcinoma] before treatment. Fluorine-18 fluorodeoxyglucose (FDG) PET was performed for comparison except in those patients with oesophageal carcinoma. For semi-quantitative analysis, the average and maximum standardised uptake values (avgSUV and maxSUV, respectively) (FLT, 114 +/- 20 min p.i.; FDG, 87 +/- 8 min p.i.; 50% isocontour region of interest) was calculated. All 17 thoracic tumours and 19/20 metastases revealed significant FLT accumulation, resulting in easy delineation from surrounding tissue. The additional small grade I renal carcinoma was not detected with either FLT or FDG. In most lung tumours (avgSUV 1.5-8.2) and metastases, FLT showed intense uptake. However, one of two spinal bone metastases was missed owing to the high physiological FLT uptake in the surrounding bone marrow. Oesophageal carcinoma primaries (avgSUV 2.7-10.0) and occasional metastases showed particularly favourable tumour/non-tumour contrast. Compared with FDG, tumour uptake of FLT was lower (avgSUV, P=0.0006; maxSUV, P=0.0001), with a significant linear correlation (avgSUV, r(2)=0.45, maxSUV, r(2)=0.49) between FLT and FDG. It is concluded that FLT PET accurately visualises thoracic tumour lesions. In the liver and the bone marrow, high physiological FLT uptake hampers detection of metastases. On the other hand, FLT may be favourable for imaging of brain metastases owing to the low physiological uptake.