Deficient distracter inhibition and enhanced facilitation for emotional stimuli in depression: An ERP study
Deficient distracter inhibition and enhanced facilitation for emotional stimuli in depression: An ERP study
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DOI：
10.1016/j.ijpsycho.2010.10.016
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发表时间：
2011-02-01
影响因子：
3
通讯作者：
Koster, Ernst H. W.
中科院分区：
文献类型：
--
作者：
Dai, Qin;Feng, Zhengzhi;Koster, Ernst H. W.
本研究采用负性情绪启动(NAP)任务和事件相关电位(ERP)相结合的方法，探讨抑郁症患者情绪面孔的分心抑制能力。在任务过程中记录反应时和事件相关电位波幅。在第一个行为实验中，对照组(NC)、目前缓解的参与者(RMD)和被诊断为当前严重抑郁障碍(MDD)的参与者执行了修改后的午睡任务。主要的发现是，与NC组相比，MOD参与者的正向启动作用更强，对悲伤表情的抑制更少。与NC个体相比，RMD个体的特征是对所有情绪面孔的普遍抑制性损害和对悲伤面孔的易化。在将改进的NAP任务与事件相关电位相结合的第二个实验中，MDD参与者在正启动条件下悲伤面孔的P1和P3波幅比其他组大，而在负启动条件下悲伤面孔的P3波幅比其他面孔小。有趣的是，与NC和MDD参与者相比，RMD参与者显示出明显的结果模式。通过实验，可以得出结论，MDD参与者缺乏分心抑制和对负面刺激的过度促进。RMD参与者表现出对积极和消极刺激缺乏分心抑制和过度促进的混合模式。这一结果与情绪材料分心抑制受损是抑郁症认知风险因素的观点是一致的。(C)2010爱思唯尔B.V.保留所有权利。
The aim of the present study was to investigate distracter inhibition ability for emotional faces in depression using a negative affective priming (NAP) task combined with event-related potentials (ERP). The reaction times and the ERP amplitudes were recorded during the task. In a first behavioral experiment, control participants (NC), participants who were currently remitted (RMD), and participants diagnosed with a current major depressive disorder (MDD), performed a modified NAP task. The main finding was that compared with the NC group, MOD participants had enhanced positive priming and less inhibition of sad faces. RMD individuals were characterized by general inhibitory impairments for all emotional faces and a facilitation for sad faces compared with NC individuals. In a second experiment combing the modified NAP task with ERP, the MDD participants had a larger P1 and P3 amplitude for sad faces in the positive priming condition compared with the other groups, and smaller P3 amplitude for sad faces in negative priming condition compared with other faces. Interestingly, RMD participants showed a distinct pattern of results compared with NC and MDD participants. Across the experiments, it can be concluded that MDD participants have deficient distracter inhibition and excessive facilitation for negative stimuli. The RMD participants show a mixed pattern of deficient distracter inhibition and excessive facilitation for both positive and negative stimuli. The results are in line with the idea that impaired distracter inhibition of emotional material is a cognitive risk factor of depression. (C) 2010 Elsevier B.V. All rights reserved.