PATTERNS OF VIREMIA AND ANTIBODY OBSERVED IN RHESUS MONKEYS INOCULATED WITH CHIKUNGUNYA AND OTHER SEROLOGICALLY RELATED GROUP A ARBOVIRUSES
PATTERNS OF VIREMIA AND ANTIBODY OBSERVED IN RHESUS MONKEYS INOCULATED WITH CHIKUNGUNYA AND OTHER SEROLOGICALLY RELATED GROUP A ARBOVIRUSES
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DOI：
10.4269/ajtmh.1967.16.782
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发表时间：
1967-01-01
影响因子：
3.3
通讯作者：
RANDALL, R
中科院分区：
文献类型：
--
作者：
BINN, LN;HARRISON, VR;RANDALL, R
通过皮下途径给年轻恒河猴接种非洲和亚洲的基孔古亚病毒株、O“nyong-nyong和Mayaro病毒。除接种O“nyong-nyong病毒的动物外，所有动物均建立了感染和病毒血症。对这些动物血清的补体结合、血凝抑制和中和试验证实了这些病毒之间的血清学关系。通过使用基孔肯雅病毒和马亚罗病毒的非洲和亚洲毒株的活病毒攻击程序证明了相互交叉保护模式。
Young rhesus monkeys were inoculated by the subcutaneous route with African and Asian strains of Chikunguya virus, O''nyong-nyong and Mayaro viruses. Infection and viremia was established in all animals except those inoculated with O''nyong-nyong virus. Complement-fixation, hemagglutination-inhibition and neutralization tests on the sera of these animals confirmed the serologic relationships between these viruses. A reciprocal cross-protection pattern was demonstrated by live virus challege procedures using the African and Asian strains of the Chikungunya virus and the Mayaro virus.