Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder.
Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder.
复制标题
岛叶皮质参与创伤后应激障碍患者陈述性记忆缺陷
DOI：
10.1186/1471-244x-9-39
复制
发表时间：
2009-06-18
期刊：
影响因子：
4.4
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Chen S;Li L;Xu B;Liu J
BackgroundNeuroimaging studies have proved that hippocampus relate to the deficient of memory in patients with post-traumatic stress disorder (PTSD). Many studies in healthy subjects also shown that insular cortex (IC) be involved in the declarative memory. This study was designed to investigate whether insular cortex is involved in declarative memory deficits in patients with PTSD.MethodsTwelve subjects with PTSD and 12 subjects without PTSD victims underwent functional magnetic resonance imaging and magnetic resonance imaging. All subjects performed encoding and retrieval memory tasks during the fMRI session. Voxel-based morphometry method was used to analyze gray-matter volume, and the Statistical Parametric Mapping (SPM2) was used to analyze activated brain areas when performing tasks.ResultsGrey matter volume was significantly reduced bilaterally in the insular cortex of PTSD subjects than non-PTSD. PTSD group also had lower level of activation in insular cortex when performing word encoding and retrieval tasks than non-PTSD group.ConclusionThe study provides evidence on structural and function abnormalities of the insular cortex in patients with PTSD. Reduced grey-matter volume in insular cortex may be associated with declarative memory deficits in patients with PTSD.
