Diadenosine polyphosphates as extracellular signal molecules
Diadenosine polyphosphates as extracellular signal molecules
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DOI：
10.1002/ddr.1123
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发表时间：
2001-01-01
影响因子：
3.8
通讯作者：
King, BF
中科院分区：
文献类型：
--
作者：
Hoyle, CHV;Hilderman, RH;King, BF
二核苷多磷酸是一组有趣的信号分子，控制着许多生理功能。二腺苷化合物，骨架由2到7个磷酸组成，已知自然存在，其中一些已从脑神经末梢分离出来，通过核苷（P1），核苷酸（P2）或二核苷酸受体起作用，可影响中枢神经系统功能。其中许多已从人血小板中分离出来的分泌颗粒酸可能参与止血机制和血管张力的外周控制。许多内脏器官对腺嘌呤二核苷酸的应用有反应，尽管它们作用于外周的受体，主要可以定义为P1或P2，但现在越来越多的证据表明它们是离散的二核苷酸受体。外周腺嘌呤二核苷酸可能是有效的激动剂，具有多种功能，引起平滑肌的收缩或松弛。许多P2X受体蛋白和P2Y受体已经被克隆，腺嘌呤二核苷酸在这些受体上具有可变的药理学特征，可能是表征P2X和P2Y受体亚型的有用工具。这篇综述提供了二腺苷多磷酸的许多细胞外作用的广泛描述，作为一个新兴的，但越来越重要的天然配体，为大量的结构多样的单核苷酸和二核苷酸受体。医药科学进展，2001,32(2):526 - 531。(C) 2001 Wiley-Liss, Inc。
Dinucleoside polyphosphates are an interesting group of signalling molecules that control numerous physiological functions. Diadenosine compounds, with a backbone of anything from two to seven phosphates, are known to occur naturally Some of them have been isolated from cerebral nerve terminals and, acting via nucleoside (P1), nucleotide (P2), or dinucleotide receptors, can affect central nervous system function. Many of them have been isolated from human blood platelet secretory granules acid are potentially involved in haemostatic mechanisms and peripheral control of vascular tone. Many visceral organs respond to the application of adenine dinucleotides and, although they act on receptors in the periphery that can be mainly defined as either P1 or P2, evidence is now accumulating for discrete dinucleotide receptors. In the periphery adenine dinucleotides can be potent agonists, with diverse functions, causing contraction or relaxation of smooth muscle. Many P2X receptor proteins and P2Y receptors have been cloned and adenine dinucleotides have a variable pharmacological profile at these receptors and may be useful tools for characterising subtypes of P2X and P2Y receptors. This review provides a broad description of the many extracellular roles of diadenosine polyphosphates as emerging, yet increasingly important, natural ligands for a plethora of structurally diverse mononucleotide and dinucleotide receptors. Drug Dev. Res. 52:260-273, 2001. (C) 2001 Wiley-Liss, Inc.