Preparation of complex porous scaffolds via selective laser sintering of poly(vinyl alcohol)/calcium silicate
Preparation of complex porous scaffolds via selective laser sintering of poly(vinyl alcohol)/calcium silicate
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DOI：
10.1177/0883911514522570
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发表时间：
2014-02
影响因子：
1.7
通讯作者：
C. Shuai;Zhongzheng Mao;Zikai Han;S. Peng
中科院分区：
文献类型：
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作者：
C. Shuai;Zhongzheng Mao;Zikai Han;S. Peng
可生物降解的聚合物/生物陶瓷复合支架可以克服聚合物支架抗压强度和生物活性较差等局限性。在这项研究中，通过选择性激光烧结成功制造了具有完全互连的多孔结构和定制形状的聚（乙烯醇）/硅酸钙（CaSiO3）复合支架。对支架的微观结构、孔隙率和机械性能进行了表征。结果表明，烧结后 CaSiO3 颗粒良好分散并嵌入到聚乙烯醇基体中。随着CaSiO3含量增加到15wt%，压缩强度增加，然后随着CaSiO3含量进一步增加到20wt%，压缩强度降低。我们的研究还表明，当 CaSiO3 含量高于 20 wt% 时，由于融合在一起的聚（乙烯醇）颗粒较少，因此无法成功制造支架。体外数据显示，聚乙烯醇/CaSiO3复合支架具有良好的生物活性和细胞相容性。
Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of polymer scaffolds such as poor compressive strength and bioactivity. In this study, poly(vinyl alcohol)/calcium silicate (CaSiO3) composite scaffolds with fully interconnected porous structures and customized shapes were successfully fabricated via selective laser sintering. The microstructure, porosity, and mechanical properties of the scaffolds were characterized. Based on the results, CaSiO3 particles were well dispersed and embedded in the poly(vinyl alcohol) matrix after sintering. The compressive strength increased with increasing the content of CaSiO3 up to 15 wt%, and then decreased with further increasing CaSiO3 content to 20 wt%. Our study also revealed that the scaffolds could not be fabricated successfully as fewer poly(vinyl alcohol) particles fused together when CaSiO3 was higher than 20 wt%. Based on the in vitro data, the poly(vinyl alcohol)/CaSiO3 composite scaffolds possess good bioactivity and cytocompatibility.