Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction
Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction
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DOI：
10.1038/ni0503-497
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发表时间：
2003
影响因子：
30.5
通讯作者：
M. Murai;H. Yoneyama;T. Ezaki;M. Suematsu;Y. Terashima;A. Harada;Hiromasa Hamada;H. Asakura;H. Ishikawa;K. Matsushima
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文献类型：
--
作者：
M. Murai;H. Yoneyama;T. Ezaki;M. Suematsu;Y. Terashima;A. Harada;Hiromasa Hamada;H. Asakura;H. Ishikawa;K. Matsushima
Acute graft-versus-host disease (a-GVHD) is initiated primarily by immunologically competent cytotoxic T cells (CTLs) that express anti-host specificities. However, the host lymphoid compartment in which these precursor CTLs are initially stimulated remains unclear. Here we show that gut Peyer's patches (PPs) are required to activate anti-host CTL responses in a well characterized murine acute graft-versus-host reaction (a-GVHR) model, involving transfer of parent lymphocytes into F1 hybrid recipients. The a-GVHR was prevented when recruitment of donor T cells into PP was interrupted either by disrupting the gene encoding chemokine receptor CCR5 or by blocking integrin α4β7–MAdCAM-1 (mucosal vascular addressin) interactions. Mice deficient for PPs failed to develop a-GVHD in two models of disease induction. Thus, blockade of CTL generation in PPs might offer new strategies for circumventing a-GVHD.
