ANTIRETROVIRAL-DRUG RESISTANCE AMONG PATIENTS RECENTLY INFECTED WITH HIV
ANTIRETROVIRAL-DRUG RESISTANCE AMONG PATIENTS RECENTLY INFECTED WITH HIV
复制标题
最近感染艾滋病毒的患者的抗逆转录病毒药物耐药性
DOI：
10.1097/00019048-200205000-00048
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发表时间：
2003
期刊：
影响因子：
8
通讯作者：
J. Church
中科院分区：
文献类型：
--
作者：
J. Church
Church JA，Cunningham C，Hughes M，et al. Pediatr Infect Dis J. 2002;21：653-659
联合抗逆转录病毒疗法的使用与人类免疫缺陷病毒（HIV）感染者的发病率和死亡率大幅下降有关。然而，在大量预治疗的受试者中，病毒通常具有导致多药耐药的逆转录酶和蛋白酶基因的多个突变。在病毒复制周期的不同阶段有效的药物...
Church JA, Cunningham C, Hughes M, et al. Pediatr Infect Dis J. 2002;21:653–659
The use of combination antiretroviral therapy has been associated with a substantial decline in morbidity and mortality in human immunodeficiency virus (HIV)-infected individuals. In heavily pretreated subjects, however, the virus often possesses multiple mutations of the reverse transcriptase and protease genes that result in multidrug resistance. Pharmacologic agents effective at alternative stages in the replication cycle of the virus …