Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs.
Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs.
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DOI：
10.1007/s00198-010-1268-4
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发表时间：
2011-02
影响因子：
4
通讯作者：
Chu, T. -M. G.
中科院分区：
文献类型：
--
作者：
Allen, M. R.;Kubek, D. J.;Burr, D. B.;Ruggiero, S. L.;Chu, T. -M. G.
本研究的目的是记录用二膦酸盐治疗如何影响拔牙后骨组织。骨骼肌发育成熟的雌性比格犬分为对照组（CON）和静脉注射唑来膦酸组（ZOL）。拔除第4颗前磨牙后，允许愈合4或8周。利用微计算机断层扫描（micro-CT）和动态组织形态测定法评估提取部位的性质。与对照组相比，ZOL对拔牙槽的初始骨填充没有影响，但随后的骨移除明显受到抑制。愈合8周后，CON动物拔牙槽附近的牙槽皮质骨的重塑率为50%/年，而ZOL治疗的动物的重塑率< 1%/年。一只接受zol治疗的动物在拔牙后出现骨暴露，最终导致残骨形成。用显微ct和组织学对残骨进行评估，发现其特征与报道的人类颌骨骨坏死一致。这些结果显示，在一只ZOL动物中，拔牙后骨愈合明显受损，暴露骨的存在和残骨的发展，为理解颌骨骨坏死的病理生理学提供了基础。
The goal of this study was to document how treatment with a bisphosphonate affects the bone tissue following dental extraction. Skeletally mature female beagle dogs were either untreated controls (CON) or treated with intravenous zoledronic acid (ZOL). Following the extraction of the 4th premolars, healing was allowed for 4 or 8 weeks. Properties of the extraction site were assessed using micro-computed tomography (micro-CT) and dynamic histomorphometry. The initial infilling of the extraction socket with bone was not affected by ZOL but subsequent removal of this bone was significantly suppressed compared to CON. After 8-weeks of healing, the alveolar cortical bone adjacent to the extraction socket had a remodeling rate of ~50%/year in CON animals while ZOL-treated animals had a rate of < 1%/year. One ZOL-treated animal developed exposed bone post-extraction which eventually led to the formation of a sequestrum. Assessment of the sequestrum with micro-CT and histology showed that it had features consistent with those reported in humans with osteonecrosis of the jaw. These results, showing significantly compromised post-extraction osseous healing as well as presence of exposed bone and development of a sequestrum in one ZOL animal, provide a building block toward understanding the pathophysiology of osteonecrosis of the jaw.
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影响因子：
1.9
作者：
Allen, Matthew R.;Burr, David B.
通讯作者：
Burr, David B.
影响因子：
3.3
作者：
Biasotto, Matteo;Chiandussi, Silvia;Di Lenarda, Roberto
通讯作者：
Di Lenarda, Roberto
影响因子：
6.2
作者：
Hoff, Ana O.;Toth, Bela B.;Hortobagyi, Gabriel N.
通讯作者：
Hortobagyi, Gabriel N.
影响因子：
6.2
作者：
Hokugo, Akishige;Christensen, Russell;Chung, Evelyn M.;Sung, Eric C.;Felsenfeld, Alan L.;Sayre, James W.;Garrett, Neal;Adams, John S.;Nishimura, Ichiro
通讯作者：
Nishimura, Ichiro
DOI：
10.14219/jada.archive.2005.0108
发表时间：
2005-12-01
影响因子：
3.9
作者：
Migliorati, CA;Casiglia, J;Woo, SB
通讯作者：
Woo, SB