LncRNA FTX activates FOXA2 expression to inhibit non-small-cell lung cancer proliferation and metastasis
LncRNA FTX activates FOXA2 expression to inhibit non-small-cell lung cancer proliferation and metastasis
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DOI：
10.1111/jcmm.15163
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发表时间：
2020-04-01
影响因子：
5.3
通讯作者：
Gao, Wen
中科院分区：
文献类型：
--
作者：
Jin, Shidai;He, Jing;Gao, Wen
肺癌是世界上死亡率最高的恶性肿瘤之一，其中非小细胞肺癌（non-small-cell lung cancer，NSCLC）占肺癌病例的80%以上。大量研究表明，长链非编码RNA（lncRNA）与包括癌症在内的多种人类疾病有关。LncRNA FTX首先在Xist基因位点被发现，并在许多人类癌症中表达异常。然而，FTX在NSCLC中的功能仍不清楚。在这里，我们报告了长链非编码RNA FTX表达水平在NSCLC临床组织样本和细胞系中下调。FTX异位表达抑制肺癌细胞增殖和转移的体内外实验研究此外，我们发现FTX过表达激活转录因子FOXA 2的表达，FOXA 2是肺癌进展中的重要调节因子，我们揭示了肺癌细胞中新的FTX/miR-200 a-3 p/FOXA 2竞争内源性RNA调节轴。我们的研究结果为探索FTX在肺癌进展中的功能提供了新的见解和方向。
Lung cancer leads to the highest mortality among all cancer types in the world, and non-small-cell lung cancer (NSCLC) occupies over 80% of the lung cancer cases. Numerous studies have demonstrated that long non-coding RNA (lncRNA) is involved in various human diseases including cancer. LncRNA FTX was firstly identified in Xist gene locus and was dysregulated in many human cancers. However, the function of FTX in NSCLC is still unclear. Here, we report that long non-coding RNA FTX expression level is down-regulated in NSCLC clinical tissue samples and cell lines. Ectopic expression of FTX inhibits proliferation and metastasis of lung cancer cells in vitro and in vivo. Furthermore, we find that FTX overexpression activates the expression of transcription factor FOXA2, an important regulator in lung cancer progression, and we reveal a novel FTX/miR-200a-3p/FOXA2 competing endogenous RNA regulatory axis in lung cancer cells. Our results provide new insights and directions for exploring the function of FTX in lung cancer progression.