Effect of Ageing on the Immune Response of Dogs to Vaccines
Effect of Ageing on the Immune Response of Dogs to Vaccines
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DOI：
10.1016/j.jcpa.2009.09.006
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发表时间：
2010-01-01
影响因子：
0.8
通讯作者：
Thompson, S.
中科院分区：
文献类型：
--
作者：
HogenEsch, H.;Thompson, S.
衰老与免疫系统功能能力的下降有关，有时称为免疫衰老。由于这增加了狗对传染病的易感性，因此确定疫苗的有效性是否受到老化的影响是很重要的。迄今为止的研究表明，老年犬对疫苗的主要反应可能会受到影响，但回忆反应仍然完好无损。需要关于年龄对接种疫苗后保护性免疫持续时间的影响的信息。(C)2009爱思唯尔有限公司保留所有权利。
Ageing is associated with a decline in functional competence of the immune system, sometimes referred to as immunosenescence. As this increase the susceptibility of dogs to infectious disease, it is important to determine if the efficacy of vaccines is affected by ageing. Studies to date suggest that the primary response to vaccines may be compromised in old dogs, but recall responses remain intact. Information on the effect of ageing on the duration of protective immunity following vaccination is needed. (C) 2009 Elsevier Ltd. All rights reserved.