RELATIONSHIP BETWEEN OVARIAN-STEROIDS, GONADOTROPINS AND RELAXIN DURING THE MENSTRUAL-CYCLE
RELATIONSHIP BETWEEN OVARIAN-STEROIDS, GONADOTROPINS AND RELAXIN DURING THE MENSTRUAL-CYCLE
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DOI：
10.1530/acta.0.1290121
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发表时间：
1993-08-01
期刊：
影响因子：
--
通讯作者：
LIGHTMAN, SL
中科院分区：
文献类型：
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作者：
JOHNSON, MR;CARTER, G;LIGHTMAN, SL
本文测定了正常月经周期血中松弛素水平，并探讨了其与血浆雌二醇(E_2)、孕酮(P)、黄体生成素(L H)和卵泡刺激素(FSH)水平的关系。此外，还研究了人绒毛膜促性腺激素(HCG)对血浆松弛素水平的影响。在研究的第一部分中，9名正常周期的女性志愿者在卵泡期的第5、10和15天，以及从清晨尿液中检测到的黄体生成素激增之日起至下一个卵泡期的第6天的隔日采集血样。在研究的第二部分，在月经周期的第11天单次肌肉注射hCG(10000IU)。从黄体中期到月经开始，都可以检测到松弛素。黄体期第10天和第12天血浆松弛素水平显著高于第6天。黄体期第8天、第10天和第12天血浆FSH水平与血浆松弛素和E2水平呈正相关，而FSH水平与松弛素和E2水平呈负相关。E_2与FSH的关系强于松弛素与FSH的关系。外源性肝癌对血浆松弛素水平无影响。雌二醇和松弛素之间的关系模式表明，一种共同的机制可能调节它们的释放，或者血浆松弛素水平由雌二醇组决定。此外，内源性黄体生成素水平和松弛素值之间没有任何关系，外源性hCG对血浆松弛素值也没有影响，这表明黄体生成素并不直接影响循环中的松弛素值。FSH与松弛素之间的负相关关系可能是由E2间接介导的，尽管松弛素可能直接影响FSH的释放。
The circulating levels of relaxin have been measured and their relationship with the plasma levels of oestradiol (E2), progesterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) have been investigated during the normal menstrual cycle. In addition, the effect of human chorionic gonadotrophin (hCG) on plasma relaxin levels has been studied. In the first part of the study, blood samples were obtained on days 5, 1 0 and 1 5 of the follicular phase and on alternate days from the day of the LH surge (detected in early-morning urine and confirmed by circulating levels of LH) until day 6 of the following follicular phase in nine normally cycling female volunteers. In the second part of the study, a single intramuscular dose of hCG (10 000 IU) was given on day 11 of the menstrual cycle. Relaxin was detectable from the mid-luteal phase until the onset of menstruation. The plasma levels of relaxin on days 10 and 12 of the luteal phase were significantly greater than on day 6. Positive associations between the circulating levels of relaxin and E2 and negative associations between the plasma levels of FSH and those of both relaxin and E2 were found on days 8, 10 and 12 of the luteal phase. The relationship between E2 and FSH was stronger than that between relaxin and FSH. Exogenous hCC had no effect on plasma relaxin levels. The pattern of the relationship between E2 and relaxin suggests that a common mechanism may regulate their release or that plasma relaxin levels are determined by those of E2. Furthermore, the absence of any relationship between endogenous LH levels and those of relaxin and the lack of effect of exogenous hCG on plasma relaxin levels suggest that LH does not influence the circulating levels of relaxin directly. The negative relationship between FSH and relaxin is probably indirect, mediated by E2, although it is possible that relaxin influences FSH release directly.