Ni-Catalyzed α-arylation of esters and amides with phenol derivatives
Ni-Catalyzed α-arylation of esters and amides with phenol derivatives
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DOI：
10.1039/c4cc08426h
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Itami, Kenichiro
中科院分区：
文献类型：
--
作者：
Koch, Eva;Takise, Ryosuke;Itami, Kenichiro
研究了镍催化的酯和酰胺与苯酚衍生物的α-芳基化反应。在由Ni（cod）（2）、3，4-双（二环己基膦基）噻吩（dcypt）和K3 PO 4原位制备的我们独特的镍催化剂的存在下，各种酯和酰胺与O-芳基新戊酸酯或O-芳基氨基甲酸酯进行α-芳基化反应，得到相应的偶联产物。由此获得的α-芳基酯和酰胺是特权基序如α-芳基羧酸和β-芳基胺的有用前体。
A nickel-catalyzed alpha-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)(2), 3,4-bis(dicyclohexyl-phosphino) thiophene (dcypt), and K3PO4, various esters and amides undergo alpha-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained alpha-aryl esters and amides are useful precursors of privileged motifs such as alpha-arylcarboxylic acids and beta-arylamines.