Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease.
Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease.
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DOI：
10.1016/j.bbadis.2019.165591
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发表时间：
2020-03
期刊：
影响因子：
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通讯作者：
Lizette E Rios;E. Emanuel Campos;R. Menon;M. Paola Zago;N. Garg
中科院分区：
文献类型：
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作者：
Lizette E Rios;E. Emanuel Campos;R. Menon;M. Paola Zago;N. Garg
Trypanos o ma cruzi(T. cruziorTc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission ofTc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission ofTcand provide a justification for the investment in the development of vaccines against congenital CD.
