Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation
Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation
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DOI：
10.7567/jjap.56.057001
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发表时间：
2017-05-01
影响因子：
1.5
通讯作者：
Ohta, Jun
中科院分区：
文献类型：
--
作者：
Haruta, Makito;Kamiyama, Naoya;Ohta, Jun
在这项研究中，我们开发了一种植入式光遗传学装置，可以测量和刺激神经元的光学方法的基础上CMOS IC技术。该装置由用于光学图案化刺激的蓝色LED阵列、用于获取脑表面图像的CMOS图像传感器和围绕CMOS图像传感器用于照明的八个绿色LED组成。蓝色LED阵列放置在CMOS图像传感器上。我们将该装置植入转基因小鼠的大脑中，并成功地展示了神经元的光学刺激，同时使用图像传感器获取大脑表面的固有光学图像。该集成装置可用于同时测量和控制活体动物中的神经元活动，这对于人工控制脑功能是重要的。(C)2017日本应用物理学会
In this study, we have developed an implantable optogenetic device that can measure and stimulate neurons by an optical method based on CMOS IC technology. The device consist of a blue LED array for optically patterned stimulation, a CMOS image sensor for acquiring brain surface image, and eight green LEDs surrounding the CMOS image sensor for illumination. The blue LED array is placed on the CMOS image sensor. We implanted the device in the brain of a genetically modified mouse and successfully demonstrated the stimulation of neurons optically and simultaneously acquire intrinsic optical images of the brain surface using the image sensor. The integrated device can be used for simultaneously measuring and controlling neuronal activities in a living animal, which is important for the artificial control of brain functions. (C) 2017 The Japan Society of Applied Physics