L-selectin: role in regulating homeostasis and cutaneous inflammation.
L-selectin: role in regulating homeostasis and cutaneous inflammation.
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DOI：
10.1016/j.jdermsci.2009.10.001
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发表时间：
2009-12
影响因子：
4.6
通讯作者：
Steeber DA
中科院分区：
文献类型：
--
作者：
Grailer JJ;Kodera M;Steeber DA
免疫监视的维持和正常免疫反应的产生依赖于白细胞向适当的淋巴和非淋巴组织的迁移。白细胞的迁移过程是通过循环中的白细胞和血管内皮细胞之间复杂和高度调节的相互作用而发生的。多个黏附分子家族以及特定的趋化物质和它们的同源受体起着稳定这些相互作用并诱导组织迁移的作用。L-选择素是一种关键的黏附分子，它既调节炎症部位白细胞的迁移，又调节淋巴细胞在血液和淋巴组织之间的循环。L-选择素介导的淋巴细胞再循环是维持包括幼稚淋巴细胞亚群和调节性T细胞等效应亚群在内的淋巴细胞亚群的适当组织分布所必需的。此外，在淋巴细胞减少期间，L-选择素介导的外周淋巴结进入是最佳的诱导淋巴细胞稳态增殖所必需的。重要的是，L-选择素在白细胞迁移过程中既具有黏附功能，又具有信号传递功能。具体地说，L-选择素高效地从血液中捕获自由流动的白细胞，并支持随后沿血管内皮细胞的快速滚动相互作用。在滚动过程中，L-选择素和整合素之间的协同作用减慢了白细胞的滚动速度，从而允许化学诱导剂诱导的激活，并最终使白细胞与血管内皮细胞牢固黏附。L-选择素与配体结合产生跨膜信号，激活细胞内信号通路，增加整合素结合亲和力，增强趋化作用。L-选择素还被证明在慢性炎症性疾病和自身免疫性疾病中介导白细胞募集，因此是药物开发的潜在治疗靶点。
The maintenance of immune surveillance and the generation of normal immune responses are dependent on leukocyte migration to appropriate lymphoid and nonlymphoid tissues. The process of leukocyte migration occurs through complex and highly regulated interactions between the circulating leukocytes and the vascular endothelium. Multiple families of adhesion molecules as well as specific chemoattractants and their cognate receptors function to stabilize these interactions and induce migration into the tissue. L-selectin is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. Specifically, L-selectin is highly efficient at capturing free-flowing leukocytes from the blood and supporting subsequent fast rolling interactions along the vascular endothelium. During rolling, synergistic interactions between L-selectin and integrin functions slow leukocyte rolling velocities allowing for chemoattractant-induced activation and eventual firm adhesion of the leukocyte to the vascular endothelium. Engagement of L-selectin by ligand generates transmembrane signals leading to activation of intracellular signaling pathways, increased integrin binding affinity, and enhanced chemotaxis. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
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影响因子：
14.2
作者：
Davenpeck, KL;Berens, KL;Bochner, BS
通讯作者：
Bochner, BS
影响因子：
5.5
作者：
Hicks, AER;Abbitt, KB;Norman, KE
通讯作者：
Norman, KE
影响因子：
6.1
作者：
Avila, PC;Boushey, HA;Fahy, JV
通讯作者：
Fahy, JV
影响因子：
4.4
作者：
Gorbachev, AV;Fairchild, RL
通讯作者：
Fairchild, RL
DOI：
10.1084/jem.194.2.205
发表时间：
2001-07-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Eriksson EE;Xie X;Werr J;Thoren P;Lindbom L
通讯作者：
Lindbom L