Incorporation of biaryl units into the 5' and 3' ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease resistance

Incorporation of biaryl units into the 5' and 3' ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease resistance
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将联芳基单位掺入 siRNA 双链体有义链和反义链的 5 和 3 末端，可提高链选择性和核酸酶抗性

DOI：
10.1021/bc100301w
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发表时间：
2011
期刊：
Bioconjugate Chem.
影响因子：
4.7
通讯作者：
Y.
Y.
中科院分区：
化学2区
文献类型：
--
作者：
Yoshikawa;K.;Ogata;A.;Matsuda;C.;Kohara;M.;Iba;H.;Kitade;Y. and Ueno;Y.

文献摘要

相似文献

小干扰RNA（small interfering RNA，siRNA）是一种非编码RNA，在治疗疑难杂症方面具有很大的潜力。如果致病基因的序列是已知的，那么siRNA可以被合理地设计和合成。在本文中，我们描述了合成和联芳基单元修饰的siRNA的性质。我们发现，将联芳基单元掺入siRNA双链体的有义链和反义链的5′和3′末端改善了链选择性和核酸酶抗性。
Small interfering RNA (siRNA) is a noncoding RNA with considerable potential as a new therapeutic drug for intractable diseases. siRNAs can be rationally designed and synthesized if the sequences of the disease-causing genes are known. In this paper, we describe the synthesis and properties of siRNAs modified with biaryl units. We found that incorporation of biaryl units into the 5′ and 3′ ends of sense and antisense strands of siRNA duplexes improved strand selectivity and nuclease resistance.