P3 event-related potential reactivity to smoking cues: Relations with craving, tobacco dependence, and alcohol sensitivity in young adult smokers.
P3 event-related potential reactivity to smoking cues: Relations with craving, tobacco dependence, and alcohol sensitivity in young adult smokers.
复制标题
P3 事件相关的对吸烟线索的潜在反应：与年轻成年吸烟者的渴望、烟草依赖和酒精敏感性的关系。
DOI：
10.1037/adb0000233
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Bartholow,BruceD
中科院分区：
文献类型：
--
作者：
Piasecki,ThomasM;Fleming,KimberlyA;Trela,ConstantineJ;Bartholow,BruceD
本研究测试了吸烟线索诱发的P3事件相关电位（ERP）的幅度是否（a）与自我报告的渴望反应程度相关，（B）受烟草依赖程度的调节。由于酒精和香烟经常一起使用，最近的证据表明，酒精敏感性的个体差异影响对酒精线索的反应，我们还调查了酒精敏感性是否调节对吸烟线索的神经反应。从年轻的成年吸烟者（N= 90），而他们参加了一个评价分类古怪的任务，涉及3种类型的目标：中性图像，吸烟相关的图像，和图像的吸管。参与者表现出较大的P3振幅吸烟线索和稻草线索（相对于中性目标）的线索曝光后，更大的渴望增加。无论是吸烟状态（日常与偶尔使用），也不烟草依赖的心理测量一致或具体缓和P3反应吸烟线索。较低的酒精敏感性与较大的P3吸烟线索，但不比较稻草线索（相对于中性目标）。烟草依赖进一步缓和了这种效应，较低的敏感性和较高的依赖性与特别明显的P3对吸烟线索的反应性相结合。研究结果表明，吸烟提示诱发的P3 ERP成分反映了一种接近导向的激励动机状态，伴随着主观的香烟渴望感。自我报告的低敏感性酒精的药理作用可能是一个标记的药物线索反应，因此值得注意的是一个潜在的主持人在吸烟线索暴露研究。
The current study tested whether the amplitude of the P3 event-related potential (ERP) elicited by smoking cues is (a) associated with the degree of self-reported craving reactivity, and (b) moderated by degree of tobacco dependence. Because alcohol and cigarettes are frequently used together, and given recent evidence indicating that individual differences in alcohol sensitivity influence reactivity to alcohol cues, we also investigated whether alcohol sensitivity moderated neural responses to smoking cues. ERPs were recorded from young adult smokers (N= 90) while they participated in an evaluative categorization oddball task involving 3 types of targets: neutral images, smoking-related images, and images of drinking straws. Participants showing larger P3 amplitudes to smoking cues and to straw cues (relative to neutral targets) reported greater increases in craving after cue exposure. Neither smoking status (daily vs. occasional use) nor psychometric measures of tobacco dependence consistently or specifically moderated P3 reactivity to smoking cues. Lower alcohol sensitivity was associated with larger P3 to smoking cues but not comparison straw cues (relative to neutral targets). This effect was further moderated by tobacco dependence, with the combination of lower sensitivity and higher dependence associated with especially pronounced P3 reactivity to smoking cues. The findings suggest the smoking-cue elicited P3 ERP component indexes an approach-oriented incentive motivational state accompanied by a subjective sense of cigarette craving. Self-reported low sensitivity to the pharmacologic effects of alcohol may represent a marker of drug cue reactivity and therefore deserves attention as a potential moderator in smoking cue exposure studies.