Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions.
Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions.
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DOI：
10.1038/s41467-017-01372-z
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发表时间：
2017-11-01
影响因子：
16.6
通讯作者：
Thordarson P
中科院分区：
文献类型：
--
作者：
Wong CK;Mason AF;Stenzel MH;Thordarson P
由两亲性嵌段共聚物组成的聚合物囊泡，由于其高稳定性、化学多功能性和表面可改性性，正在成为药物输送和合成生物学领域的强大工具。然而，由于缺乏通用的形状控制方法，聚合物囊泡的全部潜力受到阻碍。在这里，我们表明，通过利用膜结构内苝聚合物单元之间的疏水定向芳香族相互作用，可以获得一系列具有各向异性膜的非球形聚合物囊泡形态。通过改变溶剂质量来控制芳香族侧链的溶剂化/去溶剂化程度，我们证明可以轻松获得椭圆形或管状的聚合物囊泡。我们的结果表明苝芳族相互作用在非球形聚合物囊泡和其他结构复杂的自组装聚合物结构的设计中具有巨大的潜力。聚合物囊泡已成为药物输送和合成生物学中的强大工具，但由于缺乏通用的形状控制方法，它们的使用可能受到限制。在这里，作者展示了通过利用膜结构内的疏水定向芳族苝相互作用来获得一系列非球形聚合物囊泡形态。
Polymersomes, made up of amphiphilic block copolymers, are emerging as a powerful tool in drug delivery and synthetic biology due to their high stability, chemical versatility, and surface modifiability. The full potential of polymersomes, however, has been hindered by a lack of versatile methods for shape control. Here we show that a range of non-spherical polymersome morphologies with anisotropic membranes can be obtained by exploiting hydrophobic directional aromatic interactions between perylene polymer units within the membrane structure. By controlling the extent of solvation/desolvation of the aromatic side chains through changes in solvent quality, we demonstrate facile access to polymersomes that are either ellipsoidal or tubular-shaped. Our results indicate that perylene aromatic interactions have a great potential in the design of non-spherical polymersomes and other structurally complex self-assembled polymer structures. Polymersomes have become a powerful tool in drug delivery and synthetic biology, but their use can be restricted by a lack of versatile methods for shape control. Here the authors demonstrate access to a range of non-spherical polymersome morphologies by exploiting hydrophobic directional aromatic perylene interactions within the membrane structure.
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