Biochemical characteristics and function of a threonine dehydrogenase encoded by ste11 in Ebosin biosynthesis of Streptomyces sp. 139
Biochemical characteristics and function of a threonine dehydrogenase encoded by ste11 in Ebosin biosynthesis of Streptomyces sp. 139
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DOI：
10.1111/j.1365-2672.2008.04079.x
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发表时间：
2009-04
影响因子：
4
通讯作者：
Y. Bao;H. Xie;J. Shan;R. Jiang;Y. Zhang;L. Guo;R. Zhang;Y. Li
中科院分区：
文献类型：
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作者：
Y. Bao;H. Xie;J. Shan;R. Jiang;Y. Zhang;L. Guo;R. Zhang;Y. Li
目的：依博肽（Ebosin）是链霉菌139产生的一种新型胞外多糖（EPS），在体外具有白细胞介素1受体（IL-1 R）拮抗活性，在体内具有显著的抗风湿性关节炎活性。本实验室已鉴定出一个依波肽生物合成基因簇。本文报道了我们对ste 11基因功能的研究。
Aims: Ebosin, a novel exopolysaccharide (EPS) produced by Streptomyces sp. 139 has antagonistic activity for interleukin‐1 receptor (IL‐1R) in vitro and remarkable anti‐rheumatic arthritis activity in vivo. Ebosin biosynthesis gene (ste) cluster has been identified in our laboratory. This paper reports our effort to characterize the function of ste11 gene.