Epstein-Barr virus-derived EBNA2 regulates STAT3 activation
Epstein-Barr virus-derived EBNA2 regulates STAT3 activation
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DOI：
10.1016/j.bbrc.2008.11.053
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发表时间：
2009-01-16
影响因子：
3.1
通讯作者：
Matsud, Tadashi
中科院分区：
文献类型：
--
作者：
Muromoto, Ryuta;Ikeda, Osamu;Matsud, Tadashi
EB病毒（EBV）编码的潜伏蛋白EBNA 2是一种核转录激活因子，对EBV诱导的细胞转化至关重要。在这里，我们表明EBNA 2与STAT 3（白细胞介素-6家族细胞因子的信号转导子）相互作用，并通过影响其DNA结合活性来增强STAT 3的转录活性。此外，EBNA 2与LMP 1协同作用于STAT 3激活。这些数据表明EBNA 2作为STAT 3的转录共激活因子。(C)2008年爱思唯尔公司All rights reserved.
The Epstein-Barr virus (EBV)-encoded latency protein EBNA2 is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. Here, we show that EBNA2 interacts with STAT3, a signal transducer for an interleukin-6 family cytokine, and enhances the transcriptional activity of STAT3 by influencing its DNA-binding activity. Furthermore, EBNA2 cooperatively acts on STAT3 activation with LMP1, These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3. (C) 2008 Elsevier Inc. All rights reserved.