Preparation of high antimicrobial activity thiourea chitosan-Ag+ complex
Preparation of high antimicrobial activity thiourea chitosan-Ag+ complex
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DOI：
10.1016/j.carbpol.2004.11.020
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发表时间：
2005-04-07
影响因子：
11.2
通讯作者：
Zeng, HY
中科院分区：
文献类型：
--
作者：
Chen, SP;Wu, GZ;Zeng, HY
以壳聚糖和硫氰酸铵为原料，在乙醇中反应制备了硫代壳聚糖。通过Fr-IR、C-13 NMR和元素分析对硫脲壳聚糖进行了表征; XPS证实，在硫脲壳聚糖-Ag+配合物中，S原子与银离子配位，是主要的电子给体; O原子也与银离子配位，是S原子旁边的另一个电子给体。N原子不参与配位。硫代壳聚糖-Ag+络合物克服了Ag+的不稳定性。对六种细菌和霉菌的抗菌活性的复合物进行了评价。该配合物具有广谱的抗菌活性，其对细菌的MIC值分别比壳聚糖低20倍、比双乙酸钠低100倍、比苯甲酸钠低200倍，且抗菌活性优于抗真菌活性。(c)2004 Elsevier Ltd.保留所有权利。
Thiourea chitosan was prepared by the reaction of chitosan with ammonium thiocyanate in ethanol. Thiourea chitosan was characterized by Fr-IR, C-13 NMR, and elemental analysis; XPS confirmed that in thiourea chitosan-Ag+ complex, S atoms coordinated to silver ions and were the major electron donors; O atoms also coordinated to silver ions and they were another electron donors next to S atoms. N atoms did not take part in coordination. Thiourea chitosan-Ag+ complex overcomes the instability of Ag+. Antimicrobial activities of the complex was evaluated against six species of bacteria and molds. The complex showed a wide spectrum of antimicrobial activities, whose MIC values against bacteria were 20 times lower than those of chitosan, 100 times lower than those of sodium diacetate and 200 times lower than those of sodium benzoate, respectively; the complex has a better antibacterial activity than antifungal activity. (c) 2004 Elsevier Ltd. All rights reserved.