Multiple Lyotropic Polymorphism of a Poly(ethylene glycol)-Peptide Conjugate in Aqueous Solution
Multiple Lyotropic Polymorphism of a Poly(ethylene glycol)-Peptide Conjugate in Aqueous Solution
复制标题
DOI：
10.1002/adma.200800266
复制
发表时间：
2008-12-02
影响因子：
29.4
通讯作者：
Noirez, Laurence
中科院分区：
文献类型：
--
作者：
Hamley, Ian W.;Krysmann, Marta J.;Noirez, Laurence
据报道，PEG-肽缀合物形成向列相和六方柱状液晶相。结果与肽-聚合物缀合物和生物纳米材料自组装相关（与治疗应用中使用的聚乙二醇化肽相关）。淀粉样蛋白β肽的修饰片段的使用在淀粉样蛋白纤维化及其控制方面特别令人感兴趣。
Nematic and hexagonal columnar liquid crystal phase formation by a PEG-peptide conjugate is reported. The results are relevant to peptide-polymer Conjugates and bionanomaterial self-assembly (with relevance to PEGylated peptides used in therapeutic applications). The use of modified fragments of the amyloid beta peptide is especially interesting with respect to amyloid fibrillization and its control.