The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality
The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality
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DOI：
10.1016/j.mod.2012.09.002
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Carl, Matthias
中科院分区：
文献类型：
--
作者：
Huesken, Ulrike;Carl, Matthias
脊椎动物的大脑是一个非常复杂的结构，它表现出许多形态和功能的不对称性。最好的描述大脑的不对称性被发现在间脑的上丘脑，在许多物种的缰和背外侧相邻的松果体复合体是偏侧的。过去十年的研究揭示了这些结构的偏侧性及其本身的不对称性。特别是在斑马鱼（Danio rerio）中的工作大大有助于我们了解这些过程中涉及哪些遗传途径。Wnt/β-catenin通路在胚胎发育过程中对大脑的偏侧性和不对称性起着重要的调节作用。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
The vertebrate brain is an immensely complex structure, which exhibits numerous morphological and functional asymmetries. The best described brain asymmetries are found in the diencephalic epithalamus, where the habenulae and the dorso-laterally adjacent pineal complex are lateralized in many species. Research in the past decade has shed light on the establishment of the laterality of these structures as well as their asymmetry per se. In particular work in zebrafish (Danio rerio) has substantially contributed to our understanding, which genetic pathways are involved in these processes. The Wnt/beta-catenin pathway has turned out to play a pivotal role in the regulation of brain laterality and asymmetry and acts reiteratively during embryonic development. (C) 2012 Elsevier Ireland Ltd. All rights reserved.