Retinal Vascular Fractal Dimension and Its Relationship With Cardiovascular and Ocular Risk Factors
Retinal Vascular Fractal Dimension and Its Relationship With Cardiovascular and Ocular Risk Factors
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DOI：
10.1016/j.ajo.2012.04.016
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发表时间：
2012-10-01
影响因子：
4.2
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
--
作者：
Cheung, Carol Y.;Thomas, George N.;Wong, Tien Yin
目得：在新加坡Malay Eye Study.DESIGN：Population-based cross-sectional study.METHODS：视网膜血管的分形分析是一种量化视网膜血管的全球几何复杂性的方法。视网膜血管分形维数（D-f）和口径的测量从视网膜照片使用计算机辅助程序。将D-f和小动脉口径组合以形成视网膜血管最优性评分（范围从0到3）。心血管和眼部因素的数据收集从所有参与者的基础上，一个标准化的protocol.RESULTS：二千九百十三（88.8%的3280名参与者）人有足够的测量质量的视网膜照片。平均D-f为1.405（标准差为0.046;四分位数间距为1.243 - 1.542）。在多元线性回归分析中，在控制了性别、血糖、眼压、前房深度和视网膜血管口径后，较小的Df与年龄较大独立相关（标准化回归系数[s β] = -0.311; P < .001），平均动脉血压升高（s β = -0.085; P <0.001）、更近视的等效球镜（s β = 0.152; P <0.001）和存在白内障（s β = -0.107; P <0.001）。视网膜血管最优性评分与较高的平均动脉血压显著相关（趋势P > 0.001）。
PURPOSE: To examine the influence of a range of cardiovascular risk factors and ocular conditions on retinal vascular fractal dimension in the Singapore Malay Eye Study.DESIGN: Population-based cross-sectional study.METHODS: Fractal analysis of the retinal vessels is a method to quantify the global geometric complexity of the retinal vasculature. Retinal vascular fractal dimension (D-f) and caliber were measured from retinal photographs using a computer-assisted program. D-f and arteriolar caliber were combined to form a retinal vascular optimality score (ranging from 0 to 3). Data on cardiovascular and ocular factors were collected from all participants based on a standardized protocol.RESULTS: Two thousand nine hundred thirteen (88.8% of 3280 participants) persons had retinal photographs of sufficient quality for the measurement. The mean D-f was 1.405 (standard deviation, 0.046; inter-quartile range, 1.243 to 1.542). In the multiple linear regression analysis, after controlling for gender, serum glucose, intraocular pressure, anterior chamber depth, and retinal vascular caliber, smaller Df was associated independently with older age (standardized regression coefficient [s beta] = -0.311; P < .001), higher mean arterial blood pressure (s beta = -0.085; P < .001), a more myopic spherical equivalent (s beta = 0.152; P < .001), and presence of cataract (s beta = -0.107; P < .001). Retinal vascular optimality score was associated significantly with higher mean arterial blood pressure (P > .001 for trend).