Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen-Bonding Catalysis through Positive Cooperativity
Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen-Bonding Catalysis through Positive Cooperativity
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DOI：
10.1002/anie.200903063
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Smith, Martin D.
中科院分区：
文献类型：
--
作者：
Jones, Christopher R.;Pantos, G. Dan;Smith, Martin D.
一个新的转折折叠：构象良好定义的硫脲催化剂，如所示，稳定的分子内氢键表现出合作的配体-受体结合。这种构象导致显着增强的催化效率，导致更高的周转率和更低的催化剂负载，同时保持高的对映体选择性的模型反应。© 2009 Wiley-VCH Verlag GmbH and Co. KGaA.
A new twist for a fold: Conformationally well-defined thiourea catalysts, like that shown, stabilized by intramolecular hydrogen bonds demonstrate cooperative ligand-receptor binding. This conformation leads to significantly enhanced catalytic efficiency, resulting in higher turnover rates and lower catalyst loading whilst maintaining high enantioselectivity in a model reaction. © 2009 Wiley-VCH Verlag GmbH and Co. KGaA.