Loss of Runt-Related Transcription Factor 3 Causes Development and Progression of Hepatocellular Carcinoma
Loss of Runt-Related Transcription Factor 3 Causes Development and Progression of Hepatocellular Carcinoma
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DOI：
10.1002/jcb.22973
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发表时间：
2011-03-01
影响因子：
4
通讯作者：
Yamamoto, Kazuhide
中科院分区：
文献类型：
--
作者：
Shiraha, Hidenori;Nishina, Shin-ichi;Yamamoto, Kazuhide
Runt-related transcription factor 3（RUNX 3）是胃癌的抑癌基因，可能在肝细胞癌（HCC）的发生发展中起重要作用。RUNX 3基因在HCC中的表达常因其启动子的半合子缺失或高甲基化而缺失或降低。RUNX 3在肝癌中表达下降的意义尚未完全阐明，但可能与细胞周期调节功能障碍、细胞凋亡减少、血管生成增强和上皮间质转化的发展有关。RUNX 3是一个很有希望的肝癌抑制基因。J.细胞。112：745- 749，2011. (C)2010 Wiley-Liss，Inc.
Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC. J. Cell. Biochem. 112: 745-749,2011. (C) 2010 Wiley-Liss, Inc.