Comparisons between Alzheimer disease, frontotemporal lobar degeneration, and normal aging with brain mapping.
Comparisons between Alzheimer disease, frontotemporal lobar degeneration, and normal aging with brain mapping.
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DOI：
10.1097/01.rmr.0000245457.98029.e1
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Jack, Clifford R Jr
中科院分区：
文献类型：
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作者：
Whitwell, Jennifer L;Jack, Clifford R Jr
阿尔茨海默病（AD）和额颞叶变性（FTLD）都是65岁以下人群中常见的退行性痴呆。虽然这两种疾病的临床标准已经确定，但在临床特征上有相当大的重叠，因此，诊断仍然非常困难，特别是在疾病的早期阶段。因此，人们对使用磁共振成像来更好地表征这些疾病并帮助诊断的兴趣越来越大。基于体素的形态测量（VBM）是一种评估两组受试者之间磁共振成像区域灰质萎缩模式的自动化技术。它是无偏倚的，因为它观察整个大脑，不需要任何关于评估哪些结构的先验假设，这使它比传统的基于兴趣区域的方法有显著的优势。基于体素的形态学已被广泛用于评估AD和FTLD受试者的区域萎缩模式。这些研究证明了这两种疾病中区域损失的特定模式，比较了这两种疾病以寻找可能在诊断上有用的差异，并将灰质损失的区域与这些受试者的认知和行为缺陷联系起来。本文将对这些研究结果进行综述，并讨论VBM在这些神经退行性疾病中的作用。
Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) are both common degenerative dementias in the under 65 age group. Although clinical criteria have been defined for both diseases, there is considerable overlap in clinical features, and hence, diagnosis still can be very difficult particularly in the early stages of the disease. As a result, there has been increasing interest in using magnetic resonance imaging to better characterize these diseases and to aid in diagnosis. Voxel-based morphometry (VBM) is an automated technique that assesses patterns of regional gray matter atrophy on magnetic resonance imaging between 2 groups of subjects. It is unbiased in that it looks throughout the whole brain and does not require any a priori assumptions concerning which structures to assess, giving it a significant advantage over traditional region of interest-based methods. Voxel-based morphometry has been widely used to assess patterns of regional atrophy in subjects with AD and FTLD. These studies have demonstrated specific patterns of regional loss in both diseases, compared the 2 diseases to look for differences that could be diagnostically useful, and have correlated regions of gray matter loss to cognitive and behavioral deficits in these subjects. This article will review the findings of these studies and discuss the role of VBM in these neurodegenerative diseases.