Role of mast cells in otitis media
Role of mast cells in otitis media
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DOI：
10.1016/j.jaci.2005.07.026
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发表时间：
2005-11-01
影响因子：
14.2
通讯作者：
Wasserman, S
中科院分区：
文献类型：
--
作者：
Ebmeyer, J;Furukawa, M;Wasserman, S
背景：需要新的病理生理概念来解释过敏性透明和中耳炎之间的临床观察到的联系。尽管与淋巴细胞不同的肥大细胞在正常的中耳粘膜中很常见，但它们在中耳的先天免疫中的潜在作用以及在该空间中对细菌挑战的炎症反应表达的作用，与过敏相对较少， .obigntive：在当前的研究中，我们检查了肥大细胞对中耳细菌诱导炎症的发病机理的贡献介质。方法：野生型小鼠，肥大细胞缺陷的小鼠和肥大细胞缺陷的小鼠，其肥大细胞群通过骨髓衍生的肥大细胞的移植来恢复肥大细胞群，并使用细菌和过敏性中耳炎症模型来挑战：我们的结果表明，肥大细胞占中间细菌的先天免疫反应的很大比例EAR。结论：这种机制可能会将中耳粘膜过敏和感染的反应联系起来，因此肥大细胞可能是中耳炎发病机理中的关键控制元件。
Background: New pathophysiologic concepts are needed to explain the clinically observed connection between the allergic diathesis and otitis media. Although mast cells, unlike lymphocytes, are common in the normal middle ear mucosa, their potential role in innate immunity of the middle ear and in the expression of inflammatory responses in that space to bacterial challenge, as opposed to allergy, has received relatively little attention.Objective: In the current study, we examine the contributions of mast cells to the pathogenesis of bacterially induced inflammation in the middle ear and thus to otitis media.Methods: Wild-type mice, mast cell-deficient mice, and mast cell-deficient mice whose mast cell populations were restored by transplantation of bone marrow-derived mast cells were challenged by using models of bacterial and allergic middle ear inflammation.Results: Our results indicate that mast cells account for a substantial proportion of the innate immune response to bacteria in the middle ear.Conclusion: This mechanism may link responses to allergy and infection in the middle ear mucosa, and thus the mast cell may be a critical control element in the pathogenesis of otitis media.