The levator ani muscle of the rat as an index of myotrophic activity of steroidal hormones.
The levator ani muscle of the rat as an index of myotrophic activity of steroidal hormones.
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大鼠的提肛肌作为类固醇激素肌营养活性的指标。
DOI：
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发表时间：
1950
期刊：
影响因子：
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通讯作者：
G. Gordan
中科院分区：
文献类型：
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作者：
E. Eisenberg;G. Gordan
1.本文研究了去势和不同激素对雄性大鼠肛提肌重量和含水量的影响。在60天时，阉割大鼠的这种肌肉明显小于正常大鼠，并且可以通过给予某些类固醇恢复正常重量，甚至使其肥大。
2.肛提肌对各种类固醇给药的重量反应与其已知的蛋白质合成代谢活性密切相关。肌营养作用不同于雄激素作用。
3.通过该测定，垂体生长激素、未酯化睾酮、丙酸睾酮和甲基睾酮是有效的肌营养剂;孕酮是中等活性的;而二丙酸雌二醇、顺式睾酮、醋酸脱氧皮质酮和乙炔基睾酮不会显著增加肌肉重量。
1. The effects of castration and of various steroids upon the weight and water content of the levator ani muscle of the male rat were studied. This muscle is notably smaller in the castrate than in the normal rat at 60 days and can be restored to normal weight, or even rendered hypertrophic, by the administration of certain steroids.
2. The response in weight of the levator ani muscle to administration of various steroids parallels closely their known protein-anabolic activity. The myotrophic effect is distinct from the androgenic effect.
3. By this assay, pituitary growth hormone, unesterified testosterone, testosterone propionate and methyl testosterone are potent myotrophic agents; progesterone is moderately active; and estradiol dipropionate, cis-testosterone, desoxycorticosterone acetate, and ethinyl testosterone produce no significant increase in weight of the muscle.