Motor neurons can preferentially reinnervate cutaneous pathways
Motor neurons can preferentially reinnervate cutaneous pathways
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DOI：
10.1016/j.expneurol.2004.08.007
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发表时间：
2004-12-01
影响因子：
5.3
通讯作者：
Madison, RD
中科院分区：
文献类型：
--
作者：
Robinson, GA;Madison, RD
先前在大鼠股神经中的工作已经表明，再生的运动神经元优先地使末端神经分支再神经支配肌肉，而不是皮肤。这个过程被称为优先运动神经再支配（PMR），并已被解释为证据，再生的运动轴突可以区分雪旺细胞管，驻留在肌肉与皮肤的终端途径。然而，许多以前的工作已经混淆了运动轴突在再生期间进入目标肌肉。目前的实验通过再生运动轴突来防止肌肉接触。在这些条件下，8周，显着更多的运动神经元重新支配皮肤通路，而不是原来的肌肉通路。我们认为，皮肤和肌肉末梢通路在支持运动神经元再生的能力方面并没有本质上的不同。相反，我们认为，这是由每个神经分支提供的营养支持的相对水平，决定了运动轴突是否会留在该特定的分支。在股神经模型的背景下，我们的研究结果表明，营养支持再生运动轴突的层次结构与肌肉接触是最高的，其次是末端神经分支的长度和/或与皮肤接触。(C)2004年爱思唯尔公司All rights reserved.
Previous work in the rat femoral nerve has shown that regenerating motor neurons preferentially reinnervate a terminal nerve branch to muscle as opposed to skin. This process has been termed preferential motor reinnervation (PMR) and has been interpreted as evidence that regenerating motor axons can differentiate between Schwann cell tubes that reside in muscle versus cutaneous terminal pathways. However, much of this previous work has been confounded by motor axons having access to target muscle during the regeneration period. The present experiments prevented muscle contact by regenerating motor axons. By 8 weeks under these conditions, significantly more motor neurons reinnervated the cutaneous pathway rather than the original muscle pathway. We propose that cutaneous and muscle terminal pathways are not inherently different in terms of their ability to support regeneration of motor neurons. Rather, we suggest that it is the relative level of trophic support provided by each nerve branch that determines whether motor axons will remain in that particular branch. Within the context of the femoral nerve model, our results suggest a hierarchy of trophic support for regenerating motor axons with muscle contact being the highest, followed by the length of the terminal nerve branch and/or contact with skin. (C) 2004 Elsevier Inc. All rights reserved.