Occupational lung cancer risk for men in Germany:: Results from a pooled case-control study
Occupational lung cancer risk for men in Germany:: Results from a pooled case-control study
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DOI：
10.1093/oxfordjournals.aje.a010218
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发表时间：
2000-02-15
影响因子：
5
通讯作者：
Jöckel, KH
中科院分区：
文献类型：
--
作者：
Brüske-Hohlfeld, I;Möhner, M;Jöckel, KH
强烈怀疑职业暴露如结晶二氧化硅、柴油发动机废气、多环芳烃和人造矿物纤维会增加肺癌风险。将1988年至1996年在德国进行的两项病例对照研究合并进行联合分析。共有3，498例男性病例和3，541例男性人群对照，年龄和地区的频率匹配，被纳入研究。对所有工作和行业的终身史进行编码，并通过专家评级对职业暴露进行评估。通过条件Logistic回归计算了吸烟和石棉暴露的粗比值比和校正比值比。与工作相关的评估显示，在以下人群中，吸烟调整后的优势比在统计学上显著增加：农民;林业工人、渔民和畜牧业工人;矿工和采石工;化学品加工者;橱柜制造者和相关木材工人;金属生产者和加工者;瓦工和木匠;筑路工人、管道工和挖井工;泥水工、绝缘体工和室内装潢工;油漆工和油漆工;固定发动机和重型设备操作员;运输工人和货物装卸工;以及服务工人。关于特定职业暴露，比值比（OR）升高在人造矿物纤维组中，观察了经吸烟和石棉暴露调整后的肺癌风险（95%置信区间（CI））。（OR = 1.48，95%CI 1.17，1.88）;结晶二氧化硅（OR = 1.41，95% CI 1.22，1.62）;柴油发动机废气（OR = 1.43，95%CI 1.23，1.67）;和多环芳烃（OR = 1.53，95%CI 1.14，2.04）。石棉暴露的风险，调整吸烟也增加（OR = 1.41，95%CI 1.24，1.60）。
Occupational exposures such as crystalline silica, diesel engine exhaust, polycyclic aromatic hydrocarbons, and man-made mineral fibers are strongly suspected to increase lung cancer risk. Two case-control studies in Germany conducted between 1988 and 1996 were pooled for a joint analysis. A total of 3,498 male cases and 3,541 male population controls, frequency matched for age and region, were included in the study. The lifelong history of all jobs and industries was coded and occupational exposures were evaluated by expert rating. Odds ratios, crude and adjusted for smoking and asbestos exposure, were calculated by conditional logistic regression. Job-related evaluation showed a statistically significant increased odds ratio adjusted for smoking among farmers; forestry workers, fishermen, and livestock workers; miners and quarrymen; chemical processors; cabinet makers and related wood workers; metal producers and processors; bricklayers and carpenters; road construction workers, pipelayers and well diggers; plasterers, insulators, and upholsterers; painters and lacquerers; stationary engine and heavy equipment operators; transport workers and freight handlers; and service workers. With regard to specific occupational exposures, elevated odds ratios (OR) (95% confidence intervals (CI)) for lung cancer risk adjusted for smoking and asbestos exposure were observed for man-made mineral fibers (OR = 1.48, 95% CI 1.17, 1.88); crystalline silica (OR = 1.41, 95% CI 1.22, 1.62); diesel engine exhaust (OR = 1.43, 95% CI 1.23, 1.67); and polycyclic aromatic hydrocarbons (OR = 1.53, 95% CI 1.14, 2.04). The risk of asbestos exposure, adjusted for smoking was also increased (OR = 1.41, 95% CI 1.24, 1.60).