Hypothalamic monoamines and their metabolites in the deermouse, Peromyscus maniculatus, during daily torpor.
Hypothalamic monoamines and their metabolites in the deermouse, Peromyscus maniculatus, during daily torpor.
复制标题
鹿鼠 Peromyscus maniculatus 在日常麻木期间的下丘脑单胺及其代谢物。
DOI：
10.1007/bf01250995
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Pivorun,EB
中科院分区：
文献类型：
--
作者：
Lin,LH;Pivorun,EB
鹿鼠，进行食物配给，低于热中性和短光周期的环境温度，在低温或在日常麻木。下丘脑单胺和代谢物水平通过HPLC电化学检测进行定量。在迟钝动物中观察到多巴胺、3，4-二羟基苯乙酸和高香草酸水平（pg/μg蛋白质）显著升高。去甲肾上腺素和5-羟色胺的浓度在体温正常和体温迟钝状态之间没有显著变化。然而，5-羟色胺代谢物5-羟基吲哚-3-乙酸升高了近300%。这些数据表明，增加活动的下丘脑多巴胺能和多巴胺能系统发生在每日的麻木在鹿鼠。
Deermice, subjected to food rationing, an ambient temperature below thermal neutrality and short photoperiod, were sacrificed in euthermia or during daily torpor. Hypothalamic monoamine and metabolite levels were quantified by HPLC with electrochemical detection. Significant elevations in the levels (pg/μg protein) of dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid were noted in the torpid animals. The concentrations of norepinephrine and serotonin displayed no significant alterations between the euthermic and torpid states. However, the serotonin metabolite, 5-hydroxyindole-3-acetic acid, was elevated by almost 300%. These data suggest that an increase in activity of the hypothalamic serotonergic and dopaminergic systems occurs during daily torpor in the deermouse.