The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.
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药理学简明指南 2023/24：离子通道。
DOI：
10.1111/bph.16178
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发表时间：
2023
影响因子：
7.3
通讯作者：
Alexander SPH
中科院分区：
文献类型：
--
作者：
Alexander SPH
《药理学简明指南 2023/24》是该系列两年期出版物中的第六本。 《简明指南》以表格形式提供了大约 1800 个药物靶点的关键特性以及与大约 3900 个配体的 6000 多种相互作用的简明概述。重点是选择性药理学（如果有），以及药物靶点及其配体的开放获取知识库来源的链接（https://www.guidetopharmacology.org/），它提供了靶点和配体特性的更详细视图。尽管《简明指南》有近 500 页，但与网站上提供的信息和链接相比，所提供的材料大大减少。它提供了一个永久的、可引用的、时间点的记录，在数据库更新后仍然存在。本节的完整内容可以在 http://onlinelibrary.wiley.com/doi/10.1111/bph.16178 找到。离子通道是指南划分的六大药理学靶点之一，其他靶点是：G蛋白偶联受体、核激素受体、催化受体、酶和转运蛋白。这些内容提供了有关最佳可用药理学工具的命名指南和摘要信息，以及供进一步阅读的关键参考文献和建议。 《简明指南》的横向格式旨在促进从当代材料到 2023 年中期的相关目标的比较，并取代 2021/22、2019/20、2017/18、2015/16 和 2013/14 简明指南以及之前的受体和通道指南中提供的数据。它是与国际基础与临床药理学联盟 (NC-IUPHAR) 命名和标准委员会密切合作制定的，因此在适当的情况下为人类药物靶标提供官方 IUPHAR 分类和命名。
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16178. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.