Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs
Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs
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DOI：
10.1016/j.tetlet.2011.11.055
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发表时间：
2012-02-01
影响因子：
1.8
通讯作者：
Kim, Choung U.
中科院分区：
文献类型：
--
作者：
Metobo, Sammy E.;Xu, Jie;Kim, Choung U.
Several 1'-substituted analogs of Tubercidin C-nucleosides were prepared using a highly convergent synthesis. Good to high diastereoselectivity was achieved using a variety of nucleophiles targeting the 1'-position. The source for this stereoselectivity is herein proposed. It is thought to be attributed to a temperature-dependent chelation of the incoming nucleophile to either the 2'- or 3'-benzyloxy ether of the ribose core. (C) 2011 Elsevier Ltd. All rights reserved.
