Dynamic instability of microtubules: Effect of catastrophe-suppressing drugs
Dynamic instability of microtubules: Effect of catastrophe-suppressing drugs
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DOI：
10.1103/physreve.72.051914
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发表时间：
2005-11-01
影响因子：
2.4
通讯作者：
Chowdhury, D
中科院分区：
文献类型：
--
作者：
Mishra, PK;Kunwar, A;Chowdhury, D
微管是构成细胞骨架的重要组成部分的刚性蛋白质。已知它们表现出动态不稳定性。一个稳定增长的微管可以突然开始非常迅速地解聚，这种现象被称为“灾难”。然而，通常收缩的微管被“拯救”并重新开始聚合。在这里，我们开发了一个模型的聚合-解聚动力学的微管在灾难抑制药物的存在下。在稳定状态下求解动力学方程，我们推导出精确的解析表达式的长度分布的微管与药物结合的微管蛋白亚基，以及那些微管，在生长和收缩阶段，与药物免费的纯微管蛋白亚基。我们还研究了稳态解的稳定性。
Microtubules are stiff filamentary proteins that constitute an important component of the cytoskeleton of cells. These are known to exhibit a dynamic instability. A steadily growing microtubule can suddenly start depolymerizing very rapidly; this phenomenon is known as a "catastrophe." However, often a shrinking microtubule is "rescued" and starts polymerizing again. Here we develop a model for the polymerization-depolymerization dynamics of microtubules in the presence of catastrophe-suppressing drugs. Solving the dynamical equations in the steady state, we derive exact analytical expressions for the length distributions of the microtubules tipped with drug-bound tubulin subunits as well as those of the microtubules, in the growing and shrinking phases, tipped with drug-free pure tubulin subunits. We also examine the stability of the steady-state solutions.