An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors
An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors
复制标题
以Myoferlin(MYOF)为靶点治疗恶性肿瘤的新方法
DOI：
10.2174/1568026620666200618123436
复制
发表时间：
2020-01-01
影响因子：
3.4
通讯作者：
Chen, Yihua
中科院分区：
文献类型：
--
作者：
Gu, Haijun;Peng, Yangrui;Chen, Yihua
Myoferlin （MYOF）作为ferlin家族的一员，是一种II型跨膜蛋白，在碳端具有单个跨膜结构域。研究表明，MYOF参与许多细胞膜的关键生理功能，如胞外分泌、胞吞循环、囊泡运输、膜修复、膜受体循环、分泌蛋白外排等。最近的研究还发现，MYOF在多种癌症中过表达，如结直肠癌、胰腺癌、乳腺癌、黑色素瘤、胃癌和非小细胞肺癌。MYOF的高表达与肿瘤侵袭性高、临床预后差有关。MYOF通过调节细胞膜转运的生理过程，调控与癌症密切相关的蛋白质的表达、分泌和分布，以及癌细胞的能量利用、脂质代谢等生理活动。本文简要综述了MYOF的最新研究进展，表明靶向MYOF- c2d结构域的小分子抑制剂可以选择性抑制癌细胞的增殖和迁移，MYOF可能是治疗恶性肿瘤的一个有希望的靶点。
Myoferlin (MYOF), as a member of the ferlin family, is a type II transmembrane protein with a single transmembrane domain at the carbon terminus. Studies have shown that MYOF is involved in pivotal physiological functions related to numerous cell membranes, such as extracellular secretion, endocytosis cycle, vesicle trafficking, membrane repair, membrane receptor recycling, and secreted protein efflux. Recently, the studies have also revealed that MYOF is overexpressed in a variety of cancers such as colorectal cancer, pancreatic cancer, breast cancer, melanoma, gastric cancer, and non-small-cell lung cancer. High expression of MYOF is associated with the high invasion of tumors and poor clinical prognosis. MYOF medicates the expression, secretion, and distribution of proteins, which were closely related to cancers, as well as the energy utilization of cancer cells, lipid metabolism and other physiological activities by regulating the physiological processes of membrane transport. In this short article, we briefly summarize the latest progress related to MYOF, indicating that small molecule inhibitors targeting the MYOF-C2D domain can selectively inhibit the proliferation and migration of cancer cells, and MYOF may be a promising target for the treatment of malignant tumors.