Bartonella infection in domestic cats and wild felids
Bartonella infection in domestic cats and wild felids
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DOI：
10.1196/annals.1374.080
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Molia, Sophie
中科院分区：
文献类型：
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作者：
Chomel, Brtyno B.;Kasten, Rickie W.;Molia, Sophie
巴尔通体是媒介传播的、苛养的革兰氏阴性细菌，在其储存宿主中引起持续性菌血症。猫科动物是几种巴尔通体的主要宿主。家猫是B的主要宿主。henselae，猫抓病的病原体。在最适合猫蚤生存的温暖和潮湿气候中，感染率最高，因为跳蚤是感染传播的关键。跳蚤粪便是可能的感染基质。B的患病率。猫种群中的henselae基因型在世界范围内变化。基因型休斯顿I在远东更为普遍，基因型马赛在西欧、澳大利亚和美国西部占主导地位。猫通常无症状，但在自然或实验感染的猫中报告了葡萄膜炎、心内膜炎、神经系统体征、发热、接种部位坏死性病变、淋巴结病和生殖障碍。家猫也是B的储存库。克拉里奇菌和合并感染已被证实。B。Koehlerae已从家猫中分离出来，并在猫蚤中鉴定出，并与人类心内膜炎病例有关。B。在美国和B.最近在一颗猫牙中发现了五角体DNA巴尔通体也从北美和非洲的自由放养和圈养野生猫科动物中分离出来。而B.在非洲狮子和猎豹中发现了henselae，也发现了这些野猫特有的一些菌株，导致了B的概念。henselae组，包括各种亚种，如前所述的B。vinsonii。
Bartonella are vector-borne, fastidious Gram-negative bacteria causing persistent bacteremia in their reservoir hosts. Felids represent a major reservoir for several Bartonella species. Domestic cats are the main reservoir of B. henselae, the agent of cat-scratch disease. Prevalence of infection is highest in warm and humid climates that are optimal for the survival of cat fleas, as fleas are essential for the transmission of the infection. Flea feces are the likely infectious substrate. Prevalence of B. henselae genotypes among cat populations varies worldwide. Genotype Houston I is more prevalent in the Far East and genotype Marseille is dominant in western Europe, Australia, and the western United States. Cats are usually asymptomatic, but uveitis, endocarditis, neurological signs, fever, necrotic lesions at the inoculation site, lymph adenopathy, and reproductive disorders have been reported in naturally or experimentally infected cats. Domestic cats are also the reservoir of B. clarridgeiae and co-infection has been demonstrated. B. koehlerae has been isolated from domestic cats, and was identified in cat fleas and associated with a human endocarditis case. B. bovis was isolated from a few cats in the United States and B. quintana DNA was recently identified in a cat tooth. Bartonella spp. have also been isolated from free-ranging and captive wild felids from North America and Africa. Whereas, B. henselae was identified in African lions and a cheetah, some strains specific to these wild cats have also been identified, leading to the concept of a B. henselae group including various subspecies, as previously described for B. vinsonii.