PROTEIN-KINASE-C, CALCIUM AND PHOSPHOLIPID DEGRADATION
PROTEIN-KINASE-C, CALCIUM AND PHOSPHOLIPID DEGRADATION
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DOI：
10.1016/0968-0004(92)90011-w
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发表时间：
1992-10-01
影响因子：
13.8
通讯作者：
NISHIZUKA, Y
中科院分区：
文献类型：
--
作者：
ASAOKA, Y;NAKAMURA, S;NISHIZUKA, Y
在大多数细胞中，钙信号是短暂的，而由此产生的生理反应往往持续更长时间。蛋白激酶C的持续激活被认为是维持这种细胞反应所必需的。越来越清楚的是，涉及蛋白激酶C、钙和膜磷脂降解的复杂网络可能产生维持蛋白激酶C本身活化所必需的几种分子。蛋白激酶C家族的多个成员对钙和磷脂降解产物表现出不同的反应，表明它们在细胞信号传导中具有独特的功能。
In most cells, calcium signals are transient, while the resulting physiological responses often persist longer. The sustained activation of protein kinase C has been postulated to be essential for maintaining such cellular responses. It is becoming clear that an elaborate network involving protein kinase C, calcium and degradation of membrane phospholipids may generate several molecules that are necessary for sustaining the activation of protein kinase C itself. Multiple members of the protein kinase C family show distinct responses to calcium and the phospholipid degradation products, suggesting their unique functions in cell signalling.