Reversible Fronto-occipitotemporal Signaling Complements Task Encoding and Switching under Ambiguous Cues
Reversible Fronto-occipitotemporal Signaling Complements Task Encoding and Switching under Ambiguous Cues
复制标题
DOI：
10.1093/cercor/bhab324
复制
发表时间：
2021-09-14
期刊：
影响因子：
3.7
通讯作者：
Jimura, Koji
中科院分区：
文献类型：
--
作者：
Tsumura, Kaho;Kosugi, Keita;Jimura, Koji
适应不断变化的环境包括适当提取环境信息以实现行为目标。目前尚不清楚在相关行为不明确的情况下，行为灵活性是如何指导的。使用机器学习解码器和定向功能连接的功能性大脑映射，我们表明，在模糊变化的环境中，全脑可逆神经信号支持任务编码和行为灵活性。当相关行为在行为转变过程中被模糊地提示时，神经编码在分布式皮层区域中被减弱，但是来自前额叶皮层的自上而下的信号补充了编码。当行为转变被更明确地暗示时，模态专用的枕颞区执行关于相关行为的不同神经编码，并且从枕颞区到前额叶皮层的自下而上的信号补充了行为转变。这些结果表明，我们对不断变化的世界的适应是由额枕颞回路中自上而下和自下而上的信号交替进行的，这取决于环境信息的可用性。
Adaptation to changing environments involves the appropriate extraction of environmental information to achieve a behavioral goal. It remains unclear how behavioral flexibility is guided under situations where the relevant behavior is ambiguous. Using functional brain mapping of machine learning decoders and directional functional connectivity, we show that brain-wide reversible neural signaling underpins task encoding and behavioral flexibility in ambiguously changing environments. When relevant behavior is cued ambiguously during behavioral shifting, neural coding is attenuated in distributed cortical regions, but top-down signals from the prefrontal cortex complement the coding. When behavioral shifting is cued more explicitly, modality-specialized occipitotemporal regions implement distinct neural coding about relevant behavior, and bottom-up signals from the occipitotemporal region to the prefrontal cortex supplement the behavioral shift. These results suggest that our adaptation to an ever-changing world is orchestrated by the alternation of top-down and bottom-up signaling in the fronto-occipitotemporal circuit depending on the availability of environmental information.