The impact of COVID-19 pandemic on the dynamic HIV care engagement among people with HIV: real-world evidence.
The impact of COVID-19 pandemic on the dynamic HIV care engagement among people with HIV: real-world evidence.
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DOI：
10.1097/qad.0000000000003491
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发表时间：
2023-05-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
现有的研究考察了COVID-19大流行对艾滋病毒护理参与的影响，这些研究往往反映了横截面状况，而缺乏纵向评估。本研究考察了大流行对护理保留和病毒抑制状态的纵向动态变化的影响。这项人群水平队列研究的电子健康记录（EHR）数据来自南卡罗来纳州的全州电子HIV/AIDS报告系统。研究人群为HIV感染者（PWH），在流行前后至少有一年的对称随访观察记录。采用多变量广义线性混合回归模型分析大流行对这些结果的影响，并对社会人口学特征和先前存在的合并症进行调整。在调整后的模型中，与大流行前相比，在大流行期间，PWH保留护理的可能性较低（调整后的比值比[aOR]：0.806，95%置信区间[CI]：0.769，0.844），病毒学失败的概率较高（aOR：1.240，95% CI：1.169，1.316）。从每个队列的相互作用效应分析结果显示，大流行的负面影响，在照顾留更严重的高合并症负担的PWH比那些没有任何合并症，同时，一个更显着的病毒学失败中观察到的PWH谁居住在城市地区比农村地区。2019冠状病毒病大流行对南卡罗来纳州PWH的护理保留和病毒抑制产生了负面影响，特别是对于患有合并症和居住在城市地区的个人。
Existing studies examining the impact of the COVID-19 pandemic on engagement in HIV care often capture cross-sectional status, while lacking longitudinal evaluations. This study examined the impact of the pandemic on the longitudinal dynamic change of retention in care and viral suppression status. The electronic health record (EHR) data of this population-level cohort study were retrieved from the statewide electronic HIV/AIDS reporting system in South Carolina. The study population was people with HIV (PWH) who had at least one year's symmetric follow-up observation record before and after the pandemic. Multivariable generalized linear mixed regression models were employed to analyze the impact of the pandemic on these outcomes, adjusting for socio-demographic characteristics and preexisting comorbidities. In the adjusted models, PWH had a lower likelihood of retention in care (adjusted odds ratio [aOR]: 0.806, 95% confidence interval [CI]: 0.769, 0.844) and a higher probability of virological failure (aOR: 1.240, 95% CI: 1.169, 1.316) during the peri-pandemic period than pre-pandemic period. Results from interaction effect analysis from each cohort revealed that the negative effect of the pandemic on retention in care was more severe among PWH with high comorbidity burden than those without any comorbidity; meanwhile, a more striking virological failure was observed among PWH who reside in urban areas than in rural areas. The COVID-19 pandemic has a negative impact on retention in care and viral suppression among PWH in South Carolina, particularly for individuals with comorbidities and residing in urban areas.
影响因子：
4.4
作者：
Matsumoto S;Nagai M;Luong DAD;Nguyen HDT;Nguyen DT;Van Dinh T;Van Tran G;Tanuma J;Pham TN;Oka S
通讯作者：
Oka S