Precuneus shares intrinsic functional architecture in humans and monkeys
Precuneus shares intrinsic functional architecture in humans and monkeys
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DOI：
10.1073/pnas.0905314106
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发表时间：
2009-11-24
影响因子：
11.1
通讯作者：
Petrides, Michael
中科院分区：
文献类型：
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作者：
Margulies, Daniel S.;Vincent, Justin L.;Petrides, Michael
来自猕猴追踪研究的证据表明，楔前叶内存在基于连接性的分区，这为人类的类似分区提供了预测。在此，我们利用从人类和猕猴收集的静息态功能磁共振成像数据，对该区域进行了功能连接性分析。在两个物种的楔前叶内都显示出三种不同的功能连接模式，每个分区都暗示着一种不同的功能作用：（i）前楔前叶，与顶上小叶、中央旁小叶和运动皮层功能连接，表明是一个感觉运动区；（ii）中楔前叶，与背外侧前额叶、背内侧前额叶和多模式的外侧顶下小叶功能连接，表明是一个认知/联合区；（iii）后楔前叶，显示出与相邻视觉皮层区域的功能连接。这些功能连接模式与后扣带回相关的更腹侧的网络不同，后扣带回与边缘结构如内侧颞叶皮层、背侧和腹内侧前额叶区域、后外侧顶下区域以及外侧颞叶皮层相连接。我们的发现与猴子的解剖示踪研究的预测一致，并支持静息态功能连接（RSFC）可能在一定程度上反映潜在的解剖结构。楔前叶内的这些分区表明，神经影像学研究将受益于把该区域视为在解剖学（以及因此在功能上）是异质的。此外，猴子和人类的功能连接网络之间的一致性为RSFC作为一种解决功能性神经解剖学跨物种比较的可行工具提供了支持。
Evidence from macaque monkey tracing studies suggests connectivity-based subdivisions within the precuneus, offering predictions for similar subdivisions in the human. Here we present functional connectivity analyses of this region using resting-state functional MRI data collected from both humans and macaque monkeys. Three distinct patterns of functional connectivity were demonstrated within the precuneus of both species, with each subdivision suggesting a discrete functional role: (i) the anterior precuneus, functionally connected with the superior parietal cortex, paracentral lobule, and motor cortex, suggesting a sensorimotor region; (ii) the central precuneus, functionally connected to the dorsolateral prefrontal, dorsomedial prefrontal, and multimodal lateral inferior parietal cortex, suggesting a cognitive/associative region; and (iii) the posterior precuneus, displaying functional connectivity with adjacent visual cortical regions. These functional connectivity patterns were differentiated from the more ventral networks associated with the posterior cingulate, which connected with limbic structures such as the medial temporal cortex, dorsal and ventromedial prefrontal regions, posterior lateral inferior parietal regions, and the lateral temporal cortex. Our findings are consistent with predictions from anatomical tracer studies in the monkey, and provide support that resting-state functional connectivity (RSFC) may in part reflect underlying anatomy. These subdivisions within the precuneus suggest that neuroimaging studies will benefit from treating this region as anatomically (and thus functionally) heterogeneous. Furthermore, the consistency between functional connectivity networks in monkeys and humans provides support for RSFC as a viable tool for addressing cross-species comparisons of functional neuroanatomy.