Multivalent Nanoparticle Networks as Ultrasensitive Enzyme Sensors
Multivalent Nanoparticle Networks as Ultrasensitive Enzyme Sensors
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DOI：
10.1002/anie.201008189
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发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Velders, Aldrik H.
中科院分区：
文献类型：
--
作者：
de la Rica, Roberto;Fratila, Raluca M.;Velders, Aldrik H.
[图解摘要]在模型生物测定中，基于Au纳米颗粒的分散，可以检测到少至23个酶分子，其灵敏度通过多价和单价超分子相互作用之间的相互作用而提高：双二茂铁基配体（红色）引起纳米颗粒簇的组装;在其氧化时，竞争的单价客体分子（蓝色）有利于形成单价相互作用以更有效地分解。
[Graphical Abstract] As few as 23 enzyme molecules could be detected on the basis of the dispersion of Au nanoparticles in a model bioassay whose sensitivity was boosted by the interplay between multivalent and monovalent supramolecular interactions: a diferrocenyl ligand (red) caused the assembly of nanoparticle clusters; upon its oxidation, a competing monovalent guest molecule (blue) favored the formation of monovalent interactions for more efficient disassembly.