The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons
The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons
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DOI：
10.1101/gad.1459706
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发表时间：
2006-10-15
影响因子：
10.5
通讯作者：
Jan, Yuh Nung
中科院分区：
文献类型：
--
作者：
Kim, Michael D.;Jan, Lily Yeh;Jan, Yuh Nung
树突表现出广泛的形态多样性，其树枝化模式是正确的神经连接的关键决定因素。不同的神经元如何在发育过程中获得其独特的树突分支模式还没有很好的理解。在这里，我们报告说，无刺（Ss），果蝇同源的哺乳动物芳香烃（二恶英）受体（Ahr），调节树突多样性的树突树枝化（da）感觉神经元。在功能缺失的SS突变体中，I类和II类DA神经元通常以其简单的树突形态为特征，阐述了更复杂的乔木，而通常复杂的III类和IV类DA神经元则发展出更简单的树突乔木。因此，不同种类的多巴胺神经元精心制作具有相似形态的树突。在控制da神经元树突多样性的过程中，ss可能独立于其已知的辅因子tango，并通过一种与cut和abrupt不同的调节程序发挥作用。这些研究结果表明，一个进化保守的作用AHR在神经元发育的树突形态的多样化。
Dendrites exhibit a wide range of morphological diversity, and their arborization patterns are critical determinants of proper neural connectivity. How different neurons acquire their distinct dendritic branching patterns during development is not well understood. Here we report that Spineless (Ss), the Drosophila homolog of the mammalian aryl hydrocarbon (dioxin) receptor (Ahr), regulates dendrite diversity in the dendritic arborization (da) sensory neurons. In loss-of-function ss mutants, class I and II da neurons, which are normally characterized by their simple dendrite morphologies, elaborate more complex arbors, whereas the normally complex class III and IV da neurons develop simpler dendritic arbors. Consequently, different classes of da neurons elaborate dendrites with similar morphologies. In its control of dendritic diversity among da neurons, ss likely acts independently of its known cofactor tango and through a regulatory program distinct from those involving cut and abrupt. These findings suggest that one evolutionarily conserved role for Ahr in neuronal development concerns the diversification of dendrite morphology.