Distinct Manifestations of Cooperative, Multidimensional Stimulus Representations in Different Auditory Forebrain Stations.
Distinct Manifestations of Cooperative, Multidimensional Stimulus Representations in Different Auditory Forebrain Stations.
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DOI：
10.1093/cercor/bhz299
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发表时间：
2020-02
期刊：
影响因子：
3.7
通讯作者：
Jonathan Y. Shih;K. Yuan;C. Atencio;C. Schreiner
中科院分区：
文献类型：
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作者：
Jonathan Y. Shih;K. Yuan;C. Atencio;C. Schreiner
经典的听觉神经元的频域感受野(STRF)通常被表示为代表单个编码刺激特征的单个线性滤波器。多滤波STRF模型可以更准确地描述初级听觉皮质(A1)神经元的刺激-反应关系，因为它们可以捕捉到多个刺激特征。为了确定多滤波处理是否是A1独有的，我们比较了单滤波和多滤波STRF模型在氯胺酮麻醉猫的内侧膝状体(MGB)、前听野(AAF)和A1中的应用。我们使用尖峰触发平均(STA)和最大信息维度(MID)方法来估计STRF。比较3个站点的第一最大信息维度(MID1)和第二最大信息维度(MID2)的基本滤波特性，发现MGBV和A1中MID2的光谱整合比AAF更广泛。在所有3个站点中，MID2峰值潜伏期均显著长于STA和MID1。2-Filter MID模型捕获了更多的信息，并在所有3个区域的许多神经元中产生了更好的预测，但与MGBv相比，AAF和A1的预测更不成比例。值得注意的是，两个MIDs之间的信息增强合作在很大程度上仅限于A1神经元。这表明这三个前脑站在处理听觉信息的方式上存在显著差异，这表现在有效和协同的多滤波处理上。
Classic spectrotemporal receptive fields (STRFs) for auditory neurons are usually expressed as a single linear filter representing a single encoded stimulus feature. Multifilter STRF models represent the stimulus-response relationship of primary auditory cortex (A1) neurons more accurately because they can capture multiple stimulus features. To determine whether multifilter processing is unique to A1, we compared the utility of single-filter versus multifilter STRF models in the medial geniculate body (MGB), anterior auditory field (AAF), and A1 of ketamine-anesthetized cats. We estimated STRFs using both spike-triggered average (STA) and maximally informative dimension (MID) methods. Comparison of basic filter properties of first maximally informative dimension (MID1) and second maximally informative dimension (MID2) in the 3 stations revealed broader spectral integration of MID2s in MGBv and A1 as opposed to AAF. MID2 peak latency was substantially longer than for STAs and MID1s in all 3 stations. The 2-filter MID model captured more information and yielded better predictions in many neurons from all 3 areas but disproportionately more so in AAF and A1 compared with MGBv. Significantly, information-enhancing cooperation between the 2 MIDs was largely restricted to A1 neurons. This demonstrates significant differences in how these 3 forebrain stations process auditory information, as expressed in effective and synergistic multifilter processing.