A meta-analysis of the association between posttraumatic stress disorder and suicidality: the role of comorbid depression
A meta-analysis of the association between posttraumatic stress disorder and suicidality: the role of comorbid depression
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DOI：
10.1016/j.comppsych.2012.02.009
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发表时间：
2012-10-01
影响因子：
7.3
通讯作者：
Tarrier, Nicholas
中科院分区：
文献类型：
--
作者：
Panagioti, Maria;Gooding, Patricia A.;Tarrier, Nicholas
目的：大量研究报告称，被诊断患有创伤后应激障碍（PTSD）的人自杀行为的频率增加。本研究的目的是，首先，提供一个全面的系统回顾和荟萃分析之间的关联PTSD诊断和自杀频率，其次，检查共病抑郁症之间的关联自杀和PTSD的作用。方法：Medline网站（2010年6月），EMBASE（2010年6月），PsycINFO（2010年6月），飞行员（2010年6月）和Web of Science（2010年6月）进行了研究，以确定PTSD和自杀之间的关联。这些研究必须包括创伤后应激障碍和自杀倾向之间关联的效应量，以纳入荟萃分析。63项研究符合纳入荟萃分析的条件。总体和亚组效应大小进行了examined.Results：一个高度显着的正相关PTSD诊断和自杀之间的关联被发现。PTSD自杀协会坚持跨研究使用不同的措施自杀，当前和终身的PTSD，精神和非精神样本，和PTSD人群暴露于不同类型的创伤。共病的抑郁症显着加重PTSDpopulation.Conclusion自杀的风险：目前的荟萃分析提供了强有力的证据表明，PTSD诊断与自杀倾向增加。共病抑郁症在PTSD自杀倾向病因学中的重要作用也得到了支持。(c)2012 Elsevier Inc. All rights reserved.
Objective: A considerable number of studies have reported an increased frequency of suicidal behaviors among individuals diagnosed with posttraumatic stress disorder (PTSD). This study aims, first, to provide a comprehensive systematic review and meta-analysis of the association between a PTSD diagnosis and frequency of suicidality and, second, to examine the role of comorbid depression in the association between suicidality and PTSD.Methods: Searches of Medline (June 2010), EMBASE (June 2010), PsycINFO (June 2010), PILOTS (June 2010), and Web of Science (June 2010) were conducted to identify studies that examined the association between PTSD and suicidality. The studies had to include an effect size of the association between PTSD and suicidality to be included in the meta-analysis. Sixty-three studies were eligible for inclusion in the meta-analysis. Overall and subgroup effect sizes were examined.Results: A highly significant positive association between a PTSD diagnosis and suicidality was found. The PTSD-suicidality association persisted across studies using different measures of suicidality, current and lifetime PTSD, psychiatric and nonpsychiatric samples, and PTSD populations exposed to different types of traumas. Comorbid major depression significantly compounded the risk for suicide in PTSD populations.Conclusion: The current meta-analysis provides strong evidence that a PTSD diagnosis is associated with increased suicidality. The crucial role of comorbid major depression in the etiology of suicidality in PTSD is also supported. (c) 2012 Elsevier Inc. All rights reserved.