Flavonoid intake and colorectal cancer risk in men and women
Flavonoid intake and colorectal cancer risk in men and women
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DOI：
10.1093/aje/kwj296
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发表时间：
2006-10-01
影响因子：
5
通讯作者：
Giovannucci, Edward
中科院分区：
文献类型：
--
作者：
Lin, Jennifer;Zhang, Shumin M.;Giovannucci, Edward
饮食中的类黄酮可以通过保护组织免受氧自由基和抑制细胞增殖来抑制癌症的发展，但关于类黄酮摄入量和结直肠癌发病率的观察性研究很少。作者前瞻性地评估了来自护士健康研究的71,976名女性和来自健康专业人员随访研究的35,425名男性摄入类黄酮与结直肠癌发病率之间的关系。饮食摄入量在1990年、1994年和1998年通过食物频率问卷进行了评估。作者使用带有时变变量的COX比例风险模型来估计结直肠癌的相对风险。在1990至2000年间，作者记录了878例结直肠癌病例(女性498例，男性380例)。在女性和男性中，总的类黄酮类摄入量与结直肠癌风险并不成反比。总黄酮类摄入量最高五分之一与最低摄入量的合并相对危险度为1.19(95%可信区间：0.94，1.49；趋势P=0.15)。个别黄酮醇的摄入量较高，包括槲皮素、杨梅素和山奈酚，也与较低的结直肠癌风险无关。这些数据几乎不支持类黄酮摄入量与结直肠癌风险之间存在关联的假设，至少在研究人群的摄入量范围内是这样。
Dietary flavonoids can inhibit cancer development by protecting tissues against free oxygen radicals and inhibiting cell proliferation, but observational studies of flavonoid intake and colorectal cancer incidence are sparse. The authors prospectively evaluated the association between intake of flavonoids and colorectal cancer incidence in 71,976 women from the Nurses' Health Study and 35,425 men from the Health Professionals Follow-Up Study. Dietary intake was assessed in 1990, 1994, and 1998 by means of a food frequency questionnaire. The authors used Cox proportional hazards models with time-varying variables to estimate relative risks of colorectal cancer. Between 1990 and 2000, the authors documented 878 incident cases of colorectal cancer (498 in women and 380 in men). Total flavonoid intake was not inversely associated with colorectal cancer risk among women and men combined. The combined relative risk for the highest quintile of total flavonoid intake compared with the lowest was 1.19 (95% confidence interval: 0.94, 1.49; p for trend = 0.15). Higher intakes of individual flavonols, including quercetin, myricetin, and kaempferol, were also not related to a lower risk of colorectal cancer. These data provide little support for the hypothesis of an association between flavonoid intake and colorectal cancer risk, at least within the ranges of intakes consumed in the populations studied.