SERUM LEVELS OF INSULIN-LIKE GROWTH-FACTOR-1 IN SUBJECTS WITH OSTEOARTHRITIS OF THE KNEE - DATA FROM THE BALTIMORE LONGITUDINAL-STUDY OF AGING
SERUM LEVELS OF INSULIN-LIKE GROWTH-FACTOR-1 IN SUBJECTS WITH OSTEOARTHRITIS OF THE KNEE - DATA FROM THE BALTIMORE LONGITUDINAL-STUDY OF AGING
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DOI：
10.1002/art.1780370811
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发表时间：
1994-08-01
影响因子：
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通讯作者：
TOBIN, JD
中科院分区：
文献类型：
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作者：
HOCHBERG, MC;LETHBRIDGECEJKU, M;TOBIN, JD
客观的。探讨血清胰岛素样生长因子1（IGF-1）水平与膝骨关节炎（OA）之间的关系。方法。比较了年龄大于或等于 20 岁的 162 名男性和 101 名女性受试者的血清 IGF-1 水平，并根据膝关节 OA 的放射学变化进行分层。结果。膝关节 OA 患者的平均血清 IGF-1 水平显着降低；然而，在调整了与年龄相关的 IGF-1 水平变化后，这些差异不再显着。结论。这些数据未能支持这样的假设：膝关节骨关节炎患者的血清 IGF-1 水平降低，与已知的年龄相关的水平变化无关。
Objective. To examine the relationship between serum levels of insulin-like growth factor 1 (IGF-1) and osteoarthritis (OA) of the knee.Methods. Serum IGF-1 levels were compared in 162 male and 101 female subjects age greater than or equal to 20 stratified by presence of radiographic changes of OA of the knee.Results. Mean serum IGF-1 levels were significantly lower in subjects with knee OA; however, after adjustment for age-related changes in IGF-1 levels, these differences were no longer significant.Conclusion. These data fail to support the hypothesis that serum IGF-1 levels are reduced in subjects with OA of the knee independent of the known age-related changes in these levels.