DOPAMINE DEPLETION, STIMULATION OR BLOCKADE IN THE RAT DISRUPTS SPATIAL NAVIGATION AND LOCOMOTION DEPENDENT UPON BEACON OR DISTAL CUES
DOPAMINE DEPLETION, STIMULATION OR BLOCKADE IN THE RAT DISRUPTS SPATIAL NAVIGATION AND LOCOMOTION DEPENDENT UPON BEACON OR DISTAL CUES
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DOI：
10.1016/0166-4328(85)90165-2
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发表时间：
1985-10-01
影响因子：
2.7
通讯作者：
DUNNETT, SB
中科院分区：
文献类型：
--
作者：
WHISHAW, IQ;DUNNETT, SB
通过脑室注射或黑质纹状体束注射6-羟基多巴胺耗尽多巴胺的大鼠，与正常大鼠在Morris游泳池试验和一系列感觉运动试验中获得和保持位置和线索导航进行比较。双侧大量多巴胺缺乏的大鼠能够精力充沛地游泳，但无法获得位置或线索任务。单侧的大鼠，虽然在习得速度上受到了损害，但最终能够将这两项任务学习到正常水平。在狮子座之前接受过任务训练的动物表现出与多巴胺耗尽程度有关的保持缺陷：在广泛耗尽后，两项任务的表现都会恶化，直到成功导航被取消，而不完全耗竭会损害但不会取消任一任务的表现。在不同的预先训练的动物组中，多巴胺拮抗剂(卤代，α-氟苯硫醇)和激动剂(阿朴吗啡，甲苯丙胺)都阻止了地点任务和线索任务的执行，尽管大鼠的敏感度存在个体差异。位置任务的表现比线索任务对干扰更敏感，无论是病变还是氟哌啶醇、α-氟苯硫醇或阿朴吗啡，但不是甲苯丙胺。在感觉运动测试中，多巴胺耗竭的大鼠在视觉上受到损害，但不是接触位置，它们对鼻子触摸和表面的定向较弱，但对远端刺激没有定向，它们在一些运动功能测试中没有动作，但当它们湿了时，它们表现出与正常大鼠一样多的梳理动作和梳理。结果表明，多巴胺缺乏可能会损害空间导航，因为它们使用远端线索进行指导的能力受到破坏。
Rats depleted of dopamine by intraventricular or nigrostriatal bundle 6-hydroxydopamine injection were compared with normal rats on acquisition and retention of place and cue navigation in the Morris swimming pool test and on a battery of sensorimotor tests. Rats with extensive bilateral dopamine depletions were able to swim vigorously, but were unable to acquire either the place or cue task. Rats with unilateral, although impaired in the rate of acquisition were eventually able to learn both tasks to the normal levels. Animals pretrained on the tasks prior to the leions displayed retention deficits that were related to the extent of dopamine depletion: after extensive depletions, performance on both tasks deteriorated until successful navigation was abolished, whereas incomplete depletions impaired but did not abolish performance on either task. In separate groups of pretrained animals, both dopamine antagonists (halperiod, .alpha.-flupenthixol) and agonists (apomorphine, metamphetamine) blocked performance on both place and cue tasks, although were individual differences in sensitivity of the rats. Performance on the place task was more sensitive to disruption than the cue task both by the lesions and by haloperidol, .alpha.-flupenthixol or apormorphine but not by metamphetamine. On the sensorimotor tests dopamine-depleted rats were impaired at visual but not contact placing, they oriented weakly to snout touches and surfaces but not to distal stimuli, and they were akinetic on a number of tests of motor function but when wet they displayed as many grooming movements and groomed as long as did normal rats. The results suggest that dopamine depletion may impair spatial navigation by a disruption of their ability to use distal cues for guidance.